HCSGD entry for CFI
1. General information
| Official gene symbol | CFI |
|---|---|
| Entrez ID | 3426 |
| Gene full name | complement factor I |
| Other gene symbols | AHUS3 C3BINA C3b-INA FI IF KAF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005044 | Scavenger receptor activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006958 | Complement activation, classical pathway | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0030449 | Regulation of complement activation | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4476745640 | 0.0444530717 | 0.9999902473 | 0.3968959634 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.1133563410 |
| GSE13712_SHEAR | Down | -0.0546035143 |
| GSE13712_STATIC | Up | 0.2658056387 |
| GSE19018 | Up | 0.0278874546 |
| GSE19899_A1 | Up | 0.0558848360 |
| GSE19899_A2 | Down | -0.3664274093 |
| PubMed_21979375_A1 | Up | 0.1085913655 |
| PubMed_21979375_A2 | Up | 0.0279403596 |
| GSE35957 | Down | -2.4181767046 |
| GSE36640 | Up | 0.1147268500 |
| GSE54402 | Up | 0.0275145198 |
| GSE9593 | Down | -0.8620928297 |
| GSE43922 | Up | 0.0214071659 |
| GSE24585 | Up | 1.7908635321 |
| GSE37065 | Down | -0.0115660662 |
| GSE28863_A1 | Up | 0.0299940738 |
| GSE28863_A2 | Up | 0.0513229156 |
| GSE28863_A3 | Down | -0.2174541229 |
| GSE28863_A4 | Down | -0.0753957807 |
| GSE48662 | Down | -0.8105468442 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018438 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025158 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029753 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
