HCSGD entry for IDS
1. General information
| Official gene symbol | IDS |
|---|---|
| Entrez ID | 3423 |
| Gene full name | iduronate 2-sulfatase |
| Other gene symbols | MPS2 SIDS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004423 | Iduronate-2-sulfatase activity | TAS | molecular_function |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006027 | Glycosaminoglycan catabolic process | TAS | biological_process |
| GO:0008484 | Sulfuric ester hydrolase activity | IEA | molecular_function |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0030204 | Chondroitin sulfate metabolic process | TAS | biological_process |
| GO:0030207 | Chondroitin sulfate catabolic process | TAS | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0005724745 | 0.9995709775 | 0.0684913636 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2741680236 |
| GSE13712_SHEAR | Up | 0.4930498103 |
| GSE13712_STATIC | Up | 0.4030330062 |
| GSE19018 | Up | 0.2449205627 |
| GSE19899_A1 | Up | 0.8238787216 |
| GSE19899_A2 | Up | 1.1888256538 |
| PubMed_21979375_A1 | Up | 0.7725307674 |
| PubMed_21979375_A2 | Up | 1.4040457090 |
| GSE35957 | Up | 0.3009683439 |
| GSE36640 | Up | 1.4224362505 |
| GSE54402 | Up | 0.5890659142 |
| GSE9593 | Up | 0.6479282866 |
| GSE43922 | Up | 0.8819355316 |
| GSE24585 | Up | 0.1076400500 |
| GSE37065 | Up | 0.3821677630 |
| GSE28863_A1 | Up | 0.4326376514 |
| GSE28863_A2 | Up | 0.0327405871 |
| GSE28863_A3 | Up | 0.5169742108 |
| GSE28863_A4 | Up | 0.0893135208 |
| GSE48662 | Up | 0.3357752821 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021420 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023349 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025141 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043693 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051099 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8357345 | We propose that the primary defect in WS is a mutation in a gene for a trans-acting repressor protein that reduces its binding affinity for shared regulatory regions of several genes, including those that encode inhibitors of DNA synthesis (IDS) |
| 8357345 | The mutant WS repressor triggers a sequence of premature expression of IDS and other genes, with resulting inhibition of DNA synthesis and early cellular senescence, events which occur much later in normal cells |
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