HCSGD entry for IDH1
1. General information
| Official gene symbol | IDH1 |
|---|---|
| Entrez ID | 3417 |
| Gene full name | isocitrate dehydrogenase 1 (NADP+), soluble |
| Other gene symbols | IDCD IDH IDP IDPC PICD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0004450 | Isocitrate dehydrogenase (NADP+) activity | EXP IDA IEA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005777 | Peroxisome | IDA IEA | cellular_component |
| GO:0005782 | Peroxisomal matrix | TAS | cellular_component |
| GO:0005829 | Cytosol | IDA IEA TAS | cellular_component |
| GO:0006097 | Glyoxylate cycle | IEA | biological_process |
| GO:0006099 | Tricarboxylic acid cycle | IEA | biological_process |
| GO:0006102 | Isocitrate metabolic process | IDA IEA | biological_process |
| GO:0006103 | 2-oxoglutarate metabolic process | IDA TAS | biological_process |
| GO:0006740 | NADPH regeneration | TAS | biological_process |
| GO:0006749 | Glutathione metabolic process | IEA | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0008585 | Female gonad development | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0048545 | Response to steroid hormone | IEA | biological_process |
| GO:0050661 | NADP binding | IEA | molecular_function |
| GO:0051287 | NAD binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9115387903 | 0.0200774249 | 0.9999902473 | 0.2750905132 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6859171877 |
| GSE13712_SHEAR | Down | -0.2992741435 |
| GSE13712_STATIC | Down | -0.2830124909 |
| GSE19018 | Down | -0.0064294312 |
| GSE19899_A1 | Down | -0.5127295126 |
| GSE19899_A2 | Down | -0.3021952516 |
| PubMed_21979375_A1 | Down | -1.2953614979 |
| PubMed_21979375_A2 | Down | -0.3507790761 |
| GSE35957 | Down | -0.2614476696 |
| GSE36640 | Up | 0.2250958275 |
| GSE54402 | Down | -0.5231137042 |
| GSE9593 | Up | 0.0723189553 |
| GSE43922 | Down | -0.3820316289 |
| GSE24585 | Down | -0.4499113257 |
| GSE37065 | Down | -0.0910518914 |
| GSE28863_A1 | Up | 0.0450207354 |
| GSE28863_A2 | Down | -0.2919209452 |
| GSE28863_A3 | Down | -0.1100745744 |
| GSE28863_A4 | Up | 0.1955468032 |
| GSE48662 | Down | -0.1485857879 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Isocitric Acid | DB01727 | EXPT01834 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005125 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017645 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036500 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
