HCSGD entry for IDE

1. General information

Official gene symbolIDE
Entrez ID3416
Gene full nameinsulin-degrading enzyme
Other gene symbolsINSULYSIN
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001540Beta-amyloid bindingIEAmolecular_function
GO:0001948Glycoprotein bindingIPImolecular_function
GO:0004222Metalloendopeptidase activityIDA IEAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005777PeroxisomeIDAcellular_component
GO:0005782Peroxisomal matrixIEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006508ProteolysisIDA IEAbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0008286Insulin receptor signaling pathwayNASbiological_process
GO:0008340Determination of adult lifespanIDAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010815Bradykinin catabolic processIDAbiological_process
GO:0010992Ubiquitin homeostasisIDAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016887ATPase activityIEAmolecular_function
GO:0031597Cytosolic proteasome complexIEAcellular_component
GO:0031626Beta-endorphin bindingIEAmolecular_function
GO:0032461Positive regulation of protein oligomerizationIDAbiological_process
GO:0042277Peptide bindingIPImolecular_function
GO:0042447Hormone catabolic processIEAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043130Ubiquitin bindingIPImolecular_function
GO:0043559Insulin bindingIDA IPImolecular_function
GO:0045861Negative regulation of proteolysisIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050435Beta-amyloid metabolic processIDAbiological_process
GO:0051260Protein homooligomerizationIDAbiological_process
GO:0051289Protein homotetramerizationIEAbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051603Proteolysis involved in cellular protein catabolic processIDAbiological_process
GO:1901142Insulin metabolic processIDAbiological_process
GO:1901143Insulin catabolic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70710199460.11523368030.99999024730.6502611444

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1258013611
GSE13712_SHEARDown-0.1330393388
GSE13712_STATICUp0.1442487613
GSE19018Up0.0556206768
GSE19899_A1Down-0.5069225781
GSE19899_A2Down-0.4821547374
PubMed_21979375_A1Down-0.1434197482
PubMed_21979375_A2Up0.4251302130
GSE35957Up0.0813741433
GSE36640Up0.5761909174
GSE54402Down-0.4672383145
GSE9593Down-0.0702841941
GSE43922Down-0.2047534816
GSE24585Down-0.1178471146
GSE37065Down-0.0210741290
GSE28863_A1Up0.0639190216
GSE28863_A2Up0.0958169345
GSE28863_A3Down-0.9063373610
GSE28863_A4Up0.1747085289
GSE48662Down-0.2285574412

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Insulin PorkDB00071 BTD00031 | BIOD00031
BacitracinDB00626 APRD00816

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT025720MicroarrayFunctional MTI (Weak)17612493
hsa-miR-7-5pMIMAT0000252MIRT025720MicroarrayFunctional MTI (Weak)19073608
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.