HCSGD entry for ID4

1. General information

Official gene symbolID4
Entrez ID3400
Gene full nameinhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Other gene symbolsIDB4 bHLHb27
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001085RNA polymerase II transcription factor bindingIEAmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusICcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0007405Neuroblast proliferationIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021895Cerebral cortex neuron differentiationIEAbiological_process
GO:0022010Central nervous system myelinationIEAbiological_process
GO:0034613Cellular protein localizationIEAbiological_process
GO:0045444Fat cell differentiationIEAbiological_process
GO:0045599Negative regulation of fat cell differentiationIEAbiological_process
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048712Negative regulation of astrocyte differentiationIEAbiological_process
GO:0048715Negative regulation of oligodendrocyte differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99419276620.00010178940.99999024730.0177430464

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.8008723906
GSE13712_SHEARDown-0.0484940375
GSE13712_STATICDown-0.0994831715
GSE19018Down-1.1983185050
GSE19899_A1Down-0.3390915365
GSE19899_A2Down-2.5682876950
PubMed_21979375_A1Down-1.8553590762
PubMed_21979375_A2Down-1.7918563778
GSE35957Down-1.2198378812
GSE36640Down-0.9778771190
GSE54402Up0.3244143164
GSE9593Down-2.1579264764
GSE43922Down-0.3018698736
GSE24585Down-0.8994418490
GSE37065Down-0.1705527322
GSE28863_A1Down-0.0231923959
GSE28863_A2Down-1.2018999777
GSE28863_A3Down-0.2853421697
GSE28863_A4Down-0.1521962505
GSE48662Up0.4049589553

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-590-3pMIMAT0004801MIRT016169SequencingFunctional MTI (Weak)20371350
hsa-miR-335-5pMIMAT0000765MIRT018452Reporter assay;Western blot;OtherFunctional MTI21618216
hsa-miR-340-5pMIMAT0004692MIRT019630SequencingFunctional MTI (Weak)20371350
hsa-miR-9-5pMIMAT0000441MIRT021484SequencingFunctional MTI (Weak)20371350
hsa-miR-124-3pMIMAT0000422MIRT022878MicroarrayFunctional MTI (Weak)18668037
hsa-miR-192-5pMIMAT0000222MIRT026740SequencingFunctional MTI (Weak)20371350
hsa-miR-27a-3pMIMAT0000084MIRT028697SequencingFunctional MTI (Weak)20371350
hsa-miR-324-3pMIMAT0000762MIRT042873CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045037CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24905922Results allowed us to identify Cell Division Cycle Associated 2 (CDCA2) and Inhibitor of DNA binding/differentiation type 4 (ID4) as novel targets of SAmiR-494 and SAmiR-486-5p, respectively
24122992Id4 promotes senescence and sensitivity to doxorubicin-induced apoptosis in DU145 prostate cancer cells
24122992In contrast to high Id1, Id2 and Id3 expression, the expression of Id4 is epigenetically silenced in prostate cancer
24122992In the present study we demonstrated a novel role of Id4, that of promotion of cellular senescence in prostate cancer cells
24122992MATERIALS AND METHODS: Id4 was ectopically expressed in DU145 cells (DU145+Id4)
24122992Id4 also potentiated the effect of doxorubicin induced senescence and apoptosis
24122992CONCLUSION: The absence of functional p16, pRB and p53 in DU145 suggests that Id4 could alter additional molecular pathways such as those involving E2F1 to promote senescence and increased sensitivity to doxorubicin-induced apoptosis
24122992The results of the present study support the role of Id4 as a tumor suppressor in prostate cancer
11846374Senescence is characterized by downregulation of Id4, inhibitor of DNA binding 4, and Mitf, microphthalmia-associated transcription factor, in comparison with young replicating and quiescent states
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