HCSGD entry for ID2

1. General information

Official gene symbolID2
Entrez ID3398
Gene full nameinhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Other gene symbolsGIG8 ID2A ID2H bHLHb26
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000785ChromatinIEAcellular_component
GO:0001656Metanephros developmentIEAbiological_process
GO:0001779Natural killer cell differentiationIEAbiological_process
GO:0003149Membranous septum morphogenesisIEAbiological_process
GO:0003166Bundle of His developmentIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0009649Entrainment of circadian clockIEAbiological_process
GO:0010628Positive regulation of gene expressionISSbiological_process
GO:0010629Negative regulation of gene expressionISSbiological_process
GO:0014003Oligodendrocyte developmentIEAbiological_process
GO:0019216Regulation of lipid metabolic processIEAbiological_process
GO:0021772Olfactory bulb developmentIEAbiological_process
GO:0033598Mammary gland epithelial cell proliferationISSbiological_process
GO:0043234Protein complexISScellular_component
GO:0043353Enucleate erythrocyte differentiationIEAbiological_process
GO:0043392Negative regulation of DNA bindingIEAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0044325Ion channel bindingIPImolecular_function
GO:0045578Negative regulation of B cell differentiationIEAbiological_process
GO:0045600Positive regulation of fat cell differentiationIEAbiological_process
GO:0045648Positive regulation of erythrocyte differentiationIEAbiological_process
GO:0045651Positive regulation of macrophage differentiationIEAbiological_process
GO:0045665Negative regulation of neuron differentiationISSbiological_process
GO:0045668Negative regulation of osteoblast differentiationIEAbiological_process
GO:0045777Positive regulation of blood pressureISSbiological_process
GO:0045787Positive regulation of cell cycleIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048469Cell maturationIEAbiological_process
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0048557Embryonic digestive tract morphogenesisISSbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationISSbiological_process
GO:0048663Neuron fate commitmentISSbiological_process
GO:0048711Positive regulation of astrocyte differentiationIEAbiological_process
GO:0048715Negative regulation of oligodendrocyte differentiationIEAbiological_process
GO:0060612Adipose tissue developmentIEAbiological_process
GO:0060749Mammary gland alveolus developmentISSbiological_process
GO:0061030Epithelial cell differentiation involved in mammary gland alveolus developmentISSbiological_process
GO:0061031Endodermal digestive tract morphogenesisISSbiological_process
GO:0071158Positive regulation of cell cycle arrestISSbiological_process
GO:0071285Cellular response to lithium ionIEAbiological_process
GO:0071931Positive regulation of transcription involved in G1/S transition of mitotic cell cycleICbiological_process
GO:0090398Cellular senescenceISSbiological_process
GO:2000045Regulation of G1/S transition of mitotic cell cycleIMPbiological_process
GO:2000178Negative regulation of neural precursor cell proliferationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90803331560.00009020550.99999024730.0162623288

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3463927428
GSE13712_SHEARDown-0.0070932193
GSE13712_STATICUp0.0458250512
GSE19018Down-1.0572426771
GSE19899_A1Down-2.7609406598
GSE19899_A2Down-3.0329928359
PubMed_21979375_A1Down-3.4730669751
PubMed_21979375_A2Down-4.1155833543
GSE35957Up0.0493487940
GSE36640Up0.9340372755
GSE54402Down-0.5999233493
GSE9593Down-1.8782030981
GSE43922Down-2.5736496743
GSE24585Down-1.2048988966
GSE37065Up0.1912263851
GSE28863_A1Down-0.0393122420
GSE28863_A2Up0.0033118353
GSE28863_A3Up0.1433479552
GSE28863_A4Up0.0641994570
GSE48662Down-0.2050392016

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-9-5pMIMAT0000441MIRT007060Immunoblot//Immunohistochemistry//Luciferase reporter assay//Northern blot//qRT-PCRFunctional MTI22848373
hsa-miR-103a-3pMIMAT0000101MIRT007062Immunoblot//Immunohistochemistry//Luciferase reporter assay//Northern blot//qRT-PCRFunctional MTI22848373
hsa-miR-124-3pMIMAT0000422MIRT023177MicroarrayFunctional MTI (Weak)18668037
hsa-miR-215-5pMIMAT0000272MIRT024314MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026921MicroarrayFunctional MTI (Weak)19074876
hsa-miR-378a-3pMIMAT0000732MIRT043878CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b18056640
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24122992In contrast to high Id1, Id2 and Id3 expression, the expression of Id4 is epigenetically silenced in prostate cancer
21933340Anaphase-promoting complex has been shown to ubiquitinate Id2, but E3 ubiquitin ligase(s) that ubiquitinate other Id family members are not known
15663361We also demonstrate that there is more Id2 (a negative regulator of E47) in old activated B cells
15659210Senescence was accompanied by a decline in transcript levels of the polycomb gene Bmi-1, Ets1 and Ets2 transcription factors, and Id1, Id2 and Id3 helix-loop-helix proteins, suggesting roles for these genes in maintenance of cardiomyocyte proliferative capacity
8934878These included c-fos, c-jun, Id-1, Id-2, E2F-1, and cdc2
8934878This activity of Id-1 was not shared by Id-2, a related protein, and depended on an intact HLH domain
8294468Id-1H and Id-2H seem to be human homologues of mouse Id-1 and Id-2, respectively, and have potential to encode 154 and 135 amino acid proteins
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