HCSGD entry for IRF8

1. General information

Official gene symbolIRF8
Entrez ID3394
Gene full nameinterferon regulatory factor 8
Other gene symbolsH-ICSBP ICSBP ICSBP1 IRF-8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000975Regulatory region DNA bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006909PhagocytosisIEAbiological_process
GO:0006955Immune responseIEA TASbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0030099Myeloid cell differentiationIEAbiological_process
GO:0032729Positive regulation of interferon-gamma productionIEAbiological_process
GO:0032735Positive regulation of interleukin-12 productionIEAbiological_process
GO:0042742Defense response to bacteriumIEAbiological_process
GO:0042832Defense response to protozoanIEAbiological_process
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0060261Positive regulation of transcription initiation from RNA polymerase II promoterIEAbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.54937256180.37624586070.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1672863836
GSE13712_SHEARDown-0.0534725467
GSE13712_STATICDown-0.0959491220
GSE19018Up0.1182783634
GSE19899_A1Up0.0652568201
GSE19899_A2Up0.1434903164
PubMed_21979375_A1Down-0.0192364302
PubMed_21979375_A2Down-0.1874366525
GSE35957Up0.3384337077
GSE36640Up0.0909634006
GSE54402Up0.0642133853
GSE9593Down-0.0528289768
GSE43922Up0.0125365483
GSE24585Up0.3805004193
GSE37065Up0.0595791280
GSE28863_A1Down-0.5468460184
GSE28863_A2Down-0.6561363597
GSE28863_A3Up0.3998628847
GSE28863_A4Up0.1535256898
GSE48662Down-0.0276037066

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

263438011-cooperating transcription factor, Irf8
26002684We identified a subnetwork of transcription factors, including RUNX1, IRF8, PU
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