HCSGD entry for IARS
1. General information
| Official gene symbol | IARS |
|---|---|
| Entrez ID | 3376 |
| Gene full name | isoleucyl-tRNA synthetase |
| Other gene symbols | IARS1 ILERS ILRS IRS PRO0785 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002161 | Aminoacyl-tRNA editing activity | IEA | molecular_function |
| GO:0004812 | Aminoacyl-tRNA ligase activity | IEA | molecular_function |
| GO:0004822 | Isoleucine-tRNA ligase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | IEA TAS | biological_process |
| GO:0006428 | Isoleucyl-tRNA aminoacylation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1679694123 | 0.7029609855 | 0.8088764717 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2367197500 |
| GSE13712_SHEAR | Up | 0.2173890096 |
| GSE13712_STATIC | Up | 0.2445438019 |
| GSE19018 | Up | 0.2365819580 |
| GSE19899_A1 | Up | 0.2056620773 |
| GSE19899_A2 | Up | 0.1039611558 |
| PubMed_21979375_A1 | Up | 0.0049441566 |
| PubMed_21979375_A2 | Up | 0.1797624608 |
| GSE35957 | Down | -0.0029869107 |
| GSE36640 | Up | 0.2433357779 |
| GSE54402 | Down | -0.3432542216 |
| GSE9593 | Up | 0.3638152560 |
| GSE43922 | Up | 0.1280566148 |
| GSE24585 | Down | -0.4155471215 |
| GSE37065 | Down | -0.4976081906 |
| GSE28863_A1 | Up | 0.1240228837 |
| GSE28863_A2 | Down | -0.2592855872 |
| GSE28863_A3 | Down | -0.0762792392 |
| GSE28863_A4 | Up | 0.1278231178 |
| GSE48662 | Up | 0.2208380440 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Isoleucine | DB00167 | NUTR00031 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT032046 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039498 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039819 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040670 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT042439 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042694 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043474 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046693 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048412 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052634 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
