HCSGD entry for HTR3A

1. General information

Official gene symbolHTR3A
Entrez ID3359
Gene full name5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
Other gene symbols5-HT-3 5-HT3A 5-HT3R 5HT3R HTR3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004872Receptor activityTASmolecular_function
GO:0004993Serotonin receptor activityIDAmolecular_function
GO:0005232Serotonin-activated cation-selective channel activityIEAmolecular_function
GO:0005249Voltage-gated potassium channel activityIEAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006812Cation transportTASbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007210Serotonin receptor signaling pathwayIDAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007586DigestionTASbiological_process
GO:0015276Ligand-gated ion channel activityIEAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030424AxonIEAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0042220Response to cocaineIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045471Response to ethanolIEAbiological_process
GO:0051378Serotonin bindingIDAmolecular_function
GO:0055085Transmembrane transportTASbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.54143132480.92640701720.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0383217994
GSE13712_SHEARDown-0.0107613774
GSE13712_STATICDown-0.0906308500
GSE19018Up0.1734833083
GSE19899_A1Up0.1671868376
GSE19899_A2Up0.0141263080
PubMed_21979375_A1Up0.2347160522
PubMed_21979375_A2Up0.0193593220
GSE35957Up0.2154546157
GSE36640Up0.0812495574
GSE54402Up0.0121013789
GSE9593Down-0.0219090373
GSE43922Up0.1658597851
GSE24585Up0.0312004104
GSE37065Up0.0249232588
GSE28863_A1Down-0.0456918261
GSE28863_A2Down-0.0245229482
GSE28863_A3Up0.2090491958
GSE28863_A4Up0.0551015263
GSE48662Down-0.0164128759

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ZiprasidoneDB00246 APRD00540
MethadoneDB00333 APRD00485
OlanzapineDB00334 APRD00138
ClozapineDB00363 APRD00470
MirtazapineDB00370 APRD00685
PalonosetronDB00377 APRD00351
LoxapineDB00408 APRD00574
AmoxapineDB00543 APRD00142
RocuroniumDB00728 APRD01221
DolasetronDB00757 APRD00518
GranisetronDB00889 APRD01002
OndansetronDB00904 APRD00481
AlosetronDB00969 APRD00580
MemantineDB01043 APRD00221
ChloroprocaineDB01161 APRD00404
TubocurarineDB01199 APRD00176
QuetiapineDB01224 APRD00675
AripiprazoleDB01238 APRD00638
CilansetronDB04885 -
RenzaprideDB04917 -
DDP733DB05049 -
TapentadolDB06204 -
VortioxetineDB09068 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-9-5pMIMAT0000441MIRT021413MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.