HCSGD entry for HTR1D
1. General information
| Official gene symbol | HTR1D |
|---|---|
| Entrez ID | 3352 |
| Gene full name | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
| Other gene symbols | 5-HT1D HT1DA HTR1DA HTRL RDC4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004993 | Serotonin receptor activity | IMP | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | TAS | biological_process |
| GO:0007193 | Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | IMP | biological_process |
| GO:0007268 | Synaptic transmission | IEA | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0014827 | Intestine smooth muscle contraction | IMP | biological_process |
| GO:0040012 | Regulation of locomotion | IEA | biological_process |
| GO:0042310 | Vasoconstriction | IEA | biological_process |
| GO:0050795 | Regulation of behavior | IEA | biological_process |
| GO:0051378 | Serotonin binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3003084951 | 0.7771682877 | 0.9988275631 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0345990113 |
| GSE13712_SHEAR | Up | 1.1999800584 |
| GSE13712_STATIC | Up | 0.0731864664 |
| GSE19018 | Down | -0.0072335081 |
| GSE19899_A1 | Down | -0.1806850839 |
| GSE19899_A2 | Down | -0.0495048575 |
| PubMed_21979375_A1 | Down | -0.0722837352 |
| PubMed_21979375_A2 | Down | -0.2723116352 |
| GSE35957 | Up | 0.0026404452 |
| GSE36640 | Up | 0.1349142795 |
| GSE54402 | Down | -0.0867366501 |
| GSE9593 | Up | 0.0940034260 |
| GSE43922 | Up | 0.2072356264 |
| GSE24585 | Down | -0.0048183807 |
| GSE37065 | Up | 0.0182589257 |
| GSE28863_A1 | Up | 0.3116222249 |
| GSE28863_A2 | Down | -0.0524625730 |
| GSE28863_A3 | Up | 0.1140327494 |
| GSE28863_A4 | Up | 0.1201496105 |
| GSE48662 | Up | 0.0614955427 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Eletriptan | DB00216 | APRD00945 |
| Ziprasidone | DB00246 | APRD00540 |
| Ropinirole | DB00268 | APRD00302 |
| Zolmitriptan | DB00315 | APRD00376 |
| Olanzapine | DB00334 | APRD00138 |
| Clozapine | DB00363 | APRD00470 |
| Loxapine | DB00408 | APRD00574 |
| Lisuride | DB00589 | APRD00636 |
| Ergotamine | DB00696 | APRD00677 |
| Risperidone | DB00734 | APRD00187 |
| Almotriptan | DB00918 | APRD00169 |
| Naratriptan | DB00952 | APRD00220 |
| Rizatriptan | DB00953 | APRD00008 |
| Frovatriptan | DB00998 | APRD00270 |
| Pergolide | DB01186 | APRD00663 |
| Quetiapine | DB01224 | APRD00675 |
| Aripiprazole | DB01238 | APRD00638 |
| Paliperidone | DB01267 | - |
| MAP-0004 | DB05743 | - |
| NXN-188 | DB06096 | - |
| Ketamine | DB01221 | APRD00493 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019223 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042672 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
