HCSGD entry for NDST1
1. General information
| Official gene symbol | NDST1 |
|---|---|
| Entrez ID | 3340 |
| Gene full name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 |
| Other gene symbols | HSST NST1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0000165 | MAPK cascade | IEA | biological_process |
| GO:0000271 | Polysaccharide biosynthetic process | IEA | biological_process |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006024 | Glycosaminoglycan biosynthetic process | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007224 | Smoothened signaling pathway | IEA | biological_process |
| GO:0007585 | Respiratory gaseous exchange | IEA | biological_process |
| GO:0008146 | Sulfotransferase activity | IEA | molecular_function |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | IEA | biological_process |
| GO:0015012 | Heparan sulfate proteoglycan biosynthetic process | IEA | biological_process |
| GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0019213 | Deacetylase activity | IEA | molecular_function |
| GO:0030203 | Glycosaminoglycan metabolic process | IEA TAS | biological_process |
| GO:0030210 | Heparin biosynthetic process | IEA | biological_process |
| GO:0030900 | Forebrain development | IEA | biological_process |
| GO:0030901 | Midbrain development | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0048702 | Embryonic neurocranium morphogenesis | IEA | biological_process |
| GO:0048703 | Embryonic viscerocranium morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0559760989 | 0.6035914897 | 0.5145136872 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1266946164 |
| GSE13712_SHEAR | Down | -0.0378889252 |
| GSE13712_STATIC | Down | -0.1746302955 |
| GSE19018 | Up | 0.0920404935 |
| GSE19899_A1 | Up | 0.2270926932 |
| GSE19899_A2 | Up | 0.7012835636 |
| PubMed_21979375_A1 | Down | -0.5861217451 |
| PubMed_21979375_A2 | Up | 0.3789471858 |
| GSE35957 | Up | 0.2147019895 |
| GSE36640 | Up | 0.3558196919 |
| GSE54402 | Up | 0.0701457399 |
| GSE9593 | Up | 0.3616410591 |
| GSE43922 | Up | 0.1624741495 |
| GSE24585 | Down | -0.3736525996 |
| GSE37065 | Down | -0.2713550390 |
| GSE28863_A1 | Up | 0.4808422540 |
| GSE28863_A2 | Up | 0.2551929943 |
| GSE28863_A3 | Down | -0.2928904599 |
| GSE28863_A4 | Down | -0.3509025092 |
| GSE48662 | Up | 1.3780824800 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine-3'-5'-Diphosphate | DB01812 | EXPT00370 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019989 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038435 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041309 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041897 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043530 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048917 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051465 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
