HCSGD entry for HSPG2
1. General information
| Official gene symbol | HSPG2 |
|---|---|
| Entrez ID | 3339 |
| Gene full name | heparan sulfate proteoglycan 2 |
| Other gene symbols | HSPG PLC PRCAN SJA SJS SJS1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001523 | Retinoid metabolic process | TAS | biological_process |
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001958 | Endochondral ossification | IEA | biological_process |
| GO:0002062 | Chondrocyte differentiation | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005605 | Basal lamina | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006024 | Glycosaminoglycan biosynthetic process | TAS | biological_process |
| GO:0006027 | Glycosaminoglycan catabolic process | TAS | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008104 | Protein localization | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0030204 | Chondroitin sulfate metabolic process | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA ISS | cellular_component |
| GO:0042157 | Lipoprotein metabolic process | TAS | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048704 | Embryonic skeletal system morphogenesis | IEA | biological_process |
| GO:0048738 | Cardiac muscle tissue development | IEA | biological_process |
| GO:0060351 | Cartilage development involved in endochondral bone morphogenesis | IEA | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0956753087 | 0.0065010714 | 0.6474063496 | 0.1636646226 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7579929397 |
| GSE13712_SHEAR | Down | -0.5446443626 |
| GSE13712_STATIC | Down | -0.6357570054 |
| GSE19018 | Up | 0.5441948482 |
| GSE19899_A1 | Down | -0.5871962049 |
| GSE19899_A2 | Down | -0.9431811268 |
| PubMed_21979375_A1 | Down | -1.8399137183 |
| PubMed_21979375_A2 | Down | -0.3460037808 |
| GSE35957 | Up | 0.2511897494 |
| GSE36640 | Up | 0.7097237173 |
| GSE54402 | Down | -0.0018144364 |
| GSE9593 | Up | 0.0704329018 |
| GSE43922 | Down | -1.4452306868 |
| GSE24585 | Down | -0.0859025039 |
| GSE37065 | Down | -0.7951496137 |
| GSE28863_A1 | Up | 1.4479454500 |
| GSE28863_A2 | Up | 1.1385630054 |
| GSE28863_A3 | Up | 0.2810255330 |
| GSE28863_A4 | Down | -0.4593403933 |
| GSE48662 | Up | 0.1857552200 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Palifermin | DB00039 | BTD00042 | BIOD00042 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-663a | MIMAT0003326 | MIRT007259 | Luciferase reporter assay | Functional MTI | 23436656 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018272 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 1959665 | Serum stimulated PLC gamma 1 activity was diminished in high PDL cells |
| 1959665 | Immunokinase assay of PLC gamma 1 immunoprecipitates from serum stimulated IMR 90 fibroblasts suggested that diminished enzymatic activity in high PDL cells is not due to less receptor coupled tyrosine phosphorylated PLC gamma 1 enzyme |
| 1959665 | Serum stimulated [3H]thymidine incorporation into DNA declined in parallel with the activity of PLC gamma 1, suggesting that its activation might play significant roles in this in vitro model for cellular senescence |
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