HCSGD entry for HSPE1
1. General information
| Official gene symbol | HSPE1 |
|---|---|
| Entrez ID | 3336 |
| Gene full name | heat shock 10kDa protein 1 (chaperonin 10) |
| Other gene symbols | CPN10 EPF GROES HSP10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IDA ISS | cellular_component |
| GO:0005759 | Mitochondrial matrix | IEA | cellular_component |
| GO:0006457 | Protein folding | IEA | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | NAS | biological_process |
| GO:0006950 | Response to stress | IEA | biological_process |
| GO:0006986 | Response to unfolded protein | TAS | biological_process |
| GO:0051082 | Unfolded protein binding | NAS | molecular_function |
| GO:0051087 | Chaperone binding | IPI ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5521638122 | 0.1465503818 | 0.9999902473 | 0.7396649281 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5920122335 |
| GSE13712_SHEAR | Up | 0.1917852465 |
| GSE13712_STATIC | Up | 0.3666889684 |
| GSE19018 | Down | -0.6345357483 |
| GSE19899_A1 | Up | 0.3174592962 |
| GSE19899_A2 | Down | -0.2419093427 |
| PubMed_21979375_A1 | Down | -0.1551556153 |
| PubMed_21979375_A2 | Down | -0.0591052336 |
| GSE35957 | Down | -0.4665917890 |
| GSE36640 | Down | -0.3709938448 |
| GSE54402 | Up | 0.2394250959 |
| GSE9593 | Down | -0.4681216702 |
| GSE43922 | Down | -0.0081198968 |
| GSE24585 | Down | -0.6376336423 |
| GSE37065 | Up | 0.1288906951 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1964408745 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18575266 | Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10 |
| 18575266 | These proteins include: (i) the major chaperonin Hsp60 (or P1), which was identified in mammalian cells as a protein altered in mutants resistant to microtubule inhibitors and is involved in numerous functions at the cell surface and in other compartments; (ii) the Hspl0 or Cpn10 protein, which is a co-chaperone for Hsp60 in protein folding but also serves as an early pregnancy factor in maternal serum; and (iii) the mHsp70 protein, which plays a central role in mitochondrial protein import but is also important for cellular senescence (mortalin) and antigen presentation processes |
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