HCSGD entry for HSP90AA1
1. General information
| Official gene symbol | HSP90AA1 |
|---|---|
| Entrez ID | 3320 |
| Gene full name | heat shock protein 90kDa alpha (cytosolic), class A member 1 |
| Other gene symbols | EL52 HSP86 HSP89A HSP90A HSP90N HSPC1 HSPCA HSPCAL1 HSPCAL4 HSPN Hsp89 Hsp90 LAP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000166 | Nucleotide binding | TAS | molecular_function |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0001764 | Neuron migration | IEA | biological_process |
| GO:0002134 | UTP binding | IEA | molecular_function |
| GO:0002135 | CTP binding | IEA | molecular_function |
| GO:0003009 | Skeletal muscle contraction | IEA | biological_process |
| GO:0003729 | MRNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA TAS | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005829 | Cytosol | NAS TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006457 | Protein folding | IEA | biological_process |
| GO:0006839 | Mitochondrial transport | TAS | biological_process |
| GO:0006950 | Response to stress | IEA | biological_process |
| GO:0006986 | Response to unfolded protein | NAS | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0009408 | Response to heat | IEA | biological_process |
| GO:0009651 | Response to salt stress | IEA | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0010592 | Positive regulation of lamellipodium assembly | IEA | biological_process |
| GO:0010659 | Cardiac muscle cell apoptotic process | IEA | biological_process |
| GO:0016323 | Basolateral plasma membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0016887 | ATPase activity | IDA | molecular_function |
| GO:0017098 | Sulfonylurea receptor binding | IEA | molecular_function |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0019903 | Protein phosphatase binding | IEA | molecular_function |
| GO:0030235 | Nitric-oxide synthase regulator activity | IDA | molecular_function |
| GO:0030911 | TPR domain binding | IDA TAS | molecular_function |
| GO:0031012 | Extracellular matrix | IEA | cellular_component |
| GO:0031526 | Brush border membrane | IEA | cellular_component |
| GO:0032564 | DATP binding | IEA | molecular_function |
| GO:0033160 | Positive regulation of protein import into nucleus, translocation | IEA | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0042026 | Protein refolding | TAS | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | TAS | molecular_function |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0043627 | Response to estrogen | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0044325 | Ion channel binding | IEA | molecular_function |
| GO:0045040 | Protein import into mitochondrial outer membrane | IDA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | ISS | biological_process |
| GO:0045793 | Positive regulation of cell size | IEA | biological_process |
| GO:0046209 | Nitric oxide metabolic process | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050999 | Regulation of nitric-oxide synthase activity | TAS | biological_process |
| GO:0051082 | Unfolded protein binding | IEA | molecular_function |
| GO:0051131 | Chaperone-mediated protein complex assembly | IDA | biological_process |
| GO:0060452 | Positive regulation of cardiac muscle contraction | IEA | biological_process |
| GO:0071682 | Endocytic vesicle lumen | TAS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3757178489 | 0.8883649443 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3440007757 |
| GSE13712_SHEAR | Up | 0.3355159015 |
| GSE13712_STATIC | Up | 0.4002201168 |
| GSE19018 | Up | 0.1252753937 |
| GSE19899_A1 | Up | 0.1013874025 |
| GSE19899_A2 | Down | -0.0441618433 |
| PubMed_21979375_A1 | Down | -0.1234191987 |
| PubMed_21979375_A2 | Down | -0.1465037037 |
| GSE35957 | Down | -0.2015534777 |
| GSE36640 | Down | -0.0722302229 |
| GSE54402 | Up | 0.1027677881 |
| GSE9593 | Down | -0.2191586584 |
| GSE43922 | Up | 0.0136686779 |
| GSE24585 | Down | -0.0370314234 |
| GSE37065 | Up | 0.0655654164 |
| GSE28863_A1 | Up | 0.1969744815 |
| GSE28863_A2 | Up | 0.2515040987 |
| GSE28863_A3 | Down | -0.1326092642 |
| GSE28863_A4 | Down | -0.0194402322 |
| GSE48662 | Up | 0.0222448569 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT020063 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031959 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036428 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-760 | MIMAT0004957 | MIRT036729 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT039331 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039416 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-501-5p | MIMAT0002872 | MIRT041140 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041642 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042829 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043944 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30e-5p | MIMAT0000692 | MIRT044155 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045178 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045325 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046648 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT047015 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047124 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047507 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047953 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050304 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050979 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052238 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3943 | MIMAT0018359 | MIRT052896 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24156782 | A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation |
| 24156782 | AT13387 is a novel heat shock protein 90 (Hsp90) inhibitor, which inhibits the chaperone function of Hsp90 and reduces expression of Hsp90-dependent client oncoproteins |
| 22915839 | 17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells |
| 22915839 | Hsp90 chaperone has been identified as an attractive pharmacological target to combat cancer |
| 22915839 | However, some metastatic tumors either fail to respond to Hsp90 inhibition or show recovery necessitating irreversible therapeutic strategies |
| 22915839 | Doxorubicin induced senescence signaling was mediated by p53-p21(CIP/WAF-1) and was accelerated in the absence of functional Hsp90 |
| 22915839 | Our study discusses tumor selective functions of Hsp90 and discusses irrefutable strategies of Hsp90 inhibition in anticancer treatments |
| 20974249 | Finally, we have observed an attenuation of the CHIP-associated molecular folding-refolding machinery during senescence, and supportively, inhibition of Hsp90 activity leads to rapid p53 degradation only in senescent cells |
| 18325704 | To determine the mechanism of REMFS-induced effects, analysis of the cellular heat shock response revealed Hsp90 release from the heat shock transcription factor (HSF1) |
| 18262743 | Furthermore, all three modulators tested in the present study bring about their effects by inducing stress response pathways in terms of an increase in the levels of stress proteins Hsp90, Hsp70 and heme-oxygenase-1 (HO-1), which is indicative of stress-induced hormesis bringing about the biologically beneficial effects |
| 12470835 | In comparison, the amount of Hsp90 decreased both with aging and RMHS treatment in vitro |
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