HCSGD entry for HSPA5

1. General information

Official gene symbolHSPA5
Entrez ID3309
Gene full nameheat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Other gene symbolsBIP GRP78 MIF2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002576Platelet degranulationTASbiological_process
GO:0005509Calcium ion bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIMPcellular_component
GO:0005783Endoplasmic reticulumIDA IMP TAScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005793Endoplasmic reticulum-Golgi intermediate compartmentIDAcellular_component
GO:0006200ATP catabolic processISSbiological_process
GO:0006983ER overload responseIEAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008180COP9 signalosomeIDAcellular_component
GO:0009986Cell surfaceIEAcellular_component
GO:0016887ATPase activityISSmolecular_function
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0021589Cerebellum structural organizationIEAbiological_process
GO:0021680Cerebellar Purkinje cell layer developmentIEAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030176Integral component of endoplasmic reticulum membraneIDAcellular_component
GO:0030433ER-associated ubiquitin-dependent protein catabolic processTASbiological_process
GO:0030496MidbodyIDAcellular_component
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0031398Positive regulation of protein ubiquitinationIEAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0034663Endoplasmic reticulum chaperone complexIDAcellular_component
GO:0042149Cellular response to glucose starvationIDAbiological_process
GO:0042470MelanosomeIEAcellular_component
GO:0043022Ribosome bindingIEAmolecular_function
GO:0043066Negative regulation of apoptotic processIMP TASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0051082Unfolded protein bindingTASmolecular_function
GO:0051087Chaperone bindingTASmolecular_function
GO:0051787Misfolded protein bindingIDAmolecular_function
GO:0060904Regulation of protein folding in endoplasmic reticulumTASbiological_process
GO:0071236Cellular response to antibioticIEAbiological_process
GO:0071353Cellular response to interleukin-4IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71555040080.05709411880.99999024730.4488573178

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0691431365
GSE13712_SHEARDown-0.6832454891
GSE13712_STATICDown-0.2459444474
GSE19018Down-0.0662293643
GSE19899_A1Down-0.9510904869
GSE19899_A2Down-0.9576664798
PubMed_21979375_A1Down-1.0431644041
PubMed_21979375_A2Down-1.2568843216
GSE35957Down-0.1248933586
GSE36640Down-0.0299146494
GSE54402Down-0.0998491376
GSE9593Up0.2131359554
GSE43922Down-0.0082158835
GSE24585Up0.0884721014
GSE37065Down-0.0449851682
GSE28863_A1Up0.1941543102
GSE28863_A2Up0.8539606741
GSE28863_A3Up0.1542165248
GSE28863_A4Up0.0906013533
GSE48662Up0.1634090490

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018562MicroarrayFunctional MTI (Weak)18185580
hsa-miR-16-5pMIMAT0000069MIRT031900ProteomicsFunctional MTI (Weak)18668040
hsa-miR-93-3pMIMAT0004509MIRT038848CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26515130The UPR resulted in upregulation of ER chaperones including BIP/Grp78, Grp94 and led to an activation of IRE1alpha as evidenced by spliced XBP1 mRNA with IRE1alpha-induced JNK phosphorylation
25552342The expression of GRP78 was seen in senescent BECs in PBC
23634235Amongst the genes were IRAK3, SelS, HSPA5, HERPUD1, DNAJB9, SEPR1, C18orf55, ARF4, RINT1, NXT1, CADPS2, COG6, and GLRX5
22788682ER stress was detected by assays for glucose-regulated protein 78 (GRP78), CCAAT/enhancer-binding protein homologous protein (CHOP), and growth arrest and DNA damage-inducible protein 34 (GADD34) mRNA, and transient phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha)
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