HCSGD entry for HSF2
1. General information
| Official gene symbol | HSF2 |
|---|---|
| Entrez ID | 3298 |
| Gene full name | heat shock transcription factor 2 |
| Other gene symbols | HSF 2 HSTF 2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006950 | Response to stress | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9789058774 | 0.0233975229 | 0.9999902473 | 0.2948043083 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0124589139 |
| GSE13712_SHEAR | Down | -0.2036424233 |
| GSE13712_STATIC | Up | 0.1589717159 |
| GSE19018 | Up | 0.2699148348 |
| GSE19899_A1 | Down | -0.3599938554 |
| GSE19899_A2 | Down | -0.8777157366 |
| PubMed_21979375_A1 | Down | -0.5906372723 |
| PubMed_21979375_A2 | Down | -1.6835160113 |
| GSE35957 | Down | -0.4905637134 |
| GSE36640 | Down | -0.3697990110 |
| GSE54402 | Down | -0.3060197281 |
| GSE9593 | Down | -0.0714608730 |
| GSE43922 | Down | -0.3534339355 |
| GSE24585 | Down | -0.1130965141 |
| GSE37065 | Down | -0.0236680862 |
| GSE28863_A1 | Down | -0.0644958376 |
| GSE28863_A2 | Up | 0.2759144080 |
| GSE28863_A3 | Down | -0.1192784083 |
| GSE28863_A4 | Down | -0.1049101878 |
| GSE48662 | Down | -0.3986507588 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-18a-5p | MIMAT0000072 | MIRT005361 | Immunofluorescence//In situ hybridization//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20724452 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029326 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030504 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052083 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052530 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16168601 | Western blot analysis indicated that HSF1 but not HSF2 protein levels were reduced in aged donor samples |
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