HCSGD entry for HSD17B2
1. General information
| Official gene symbol | HSD17B2 |
|---|---|
| Entrez ID | 3294 |
| Gene full name | hydroxysteroid (17-beta) dehydrogenase 2 |
| Other gene symbols | EDH17B2 HSD17 SDR9C2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001890 | Placenta development | IEA | biological_process |
| GO:0004303 | Estradiol 17-beta-dehydrogenase activity | IDA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006694 | Steroid biosynthetic process | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0032526 | Response to retinoic acid | IDA | biological_process |
| GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity | TAS | molecular_function |
| GO:0047035 | Testosterone dehydrogenase (NAD+) activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0119438471 | 0.2151797766 | 0.2735937391 | 0.8950548428 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0369336065 |
| GSE13712_SHEAR | Up | 4.4920786761 |
| GSE13712_STATIC | Up | 3.3938210612 |
| GSE19018 | Down | -0.2422443266 |
| GSE19899_A1 | Down | -1.5292848460 |
| GSE19899_A2 | Down | -0.1991195879 |
| PubMed_21979375_A1 | Down | -0.0093172671 |
| PubMed_21979375_A2 | Up | 0.8239746235 |
| GSE35957 | Up | 0.3237676142 |
| GSE36640 | Up | 3.3518670369 |
| GSE54402 | Down | -1.4455231524 |
| GSE9593 | Down | -0.0312799702 |
| GSE43922 | Up | 0.2596697886 |
| GSE24585 | Up | 0.0746984656 |
| GSE37065 | Down | -0.0769511050 |
| GSE28863_A1 | Down | -0.1723342504 |
| GSE28863_A2 | Down | -0.1843024787 |
| GSE28863_A3 | Up | 0.0511818789 |
| GSE28863_A4 | Down | -0.0036976315 |
| GSE48662 | Down | -0.0243289022 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022540 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029366 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
