HCSGD entry for HES1

1. General information

Official gene symbolHES1
Entrez ID3280
Gene full namehairy and enhancer of split 1, (Drosophila)
Other gene symbolsHES-1 HHL HRY bHLHb39
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionISSmolecular_function
GO:0001889Liver developmentIEAbiological_process
GO:0003143Embryonic heart tube morphogenesisISSbiological_process
GO:0003151Outflow tract morphogenesisISSbiological_process
GO:0003266Regulation of secondary heart field cardioblast proliferationISSbiological_process
GO:0003281Ventricular septum developmentISSbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006461Protein complex assemblyISSbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007219Notch signaling pathwayIDA IMP TASbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0007262STAT protein import into nucleusISSbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0008134Transcription factor bindingNASmolecular_function
GO:0008284Positive regulation of cell proliferationISSbiological_process
GO:0016477Cell migrationIEAbiological_process
GO:0021537Telencephalon developmentIEAbiological_process
GO:0021555Midbrain-hindbrain boundary morphogenesisIEAbiological_process
GO:0021557Oculomotor nerve developmentIEAbiological_process
GO:0021558Trochlear nerve developmentIEAbiological_process
GO:0021575Hindbrain morphogenesisIEAbiological_process
GO:0021861Forebrain radial glial cell differentiationISSbiological_process
GO:0021984Adenohypophysis developmentIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEAbiological_process
GO:0030901Midbrain developmentIEAbiological_process
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0035910Ascending aorta morphogenesisISSbiological_process
GO:0042102Positive regulation of T cell proliferationIEAbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinISSbiological_process
GO:0042668Auditory receptor cell fate determinationIEAbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043388Positive regulation of DNA bindingISSbiological_process
GO:0043565Sequence-specific DNA bindingISSmolecular_function
GO:0045598Regulation of fat cell differentiationIEAbiological_process
GO:0045608Negative regulation of auditory receptor cell differentiationIEAbiological_process
GO:0045747Positive regulation of Notch signaling pathwayIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0045977Positive regulation of mitotic cell cycle, embryonicISSbiological_process
GO:0046331Lateral inhibitionIEAbiological_process
GO:0046427Positive regulation of JAK-STAT cascadeISSbiological_process
GO:0048469Cell maturationIEAbiological_process
GO:0048538Thymus developmentISSbiological_process
GO:0048667Cell morphogenesis involved in neuron differentiationIEAbiological_process
GO:0048711Positive regulation of astrocyte differentiationISSbiological_process
GO:0048715Negative regulation of oligodendrocyte differentiationISSbiological_process
GO:0048844Artery morphogenesisISSbiological_process
GO:0060037Pharyngeal system developmentISSbiological_process
GO:0060164Regulation of timing of neuron differentiationIEAbiological_process
GO:0060253Negative regulation of glial cell proliferationISSbiological_process
GO:0060412Ventricular septum morphogenesisISSbiological_process
GO:0060675Ureteric bud morphogenesisIEAbiological_process
GO:0060716Labyrinthine layer blood vessel developmentIEAbiological_process
GO:0061009Common bile duct developmentIEAbiological_process
GO:0061106Negative regulation of stomach neuroendocrine cell differentiationIEAbiological_process
GO:0061309Cardiac neural crest cell development involved in outflow tract morphogenesisISSbiological_process
GO:0071820N-box bindingISSmolecular_function
GO:0072012Glomerulus vasculature developmentIEAbiological_process
GO:0072049Comma-shaped body morphogenesisIEAbiological_process
GO:0072050S-shaped body morphogenesisIEAbiological_process
GO:0072141Renal interstitial cell developmentIEAbiological_process
GO:0072282Metanephric nephron tubule morphogenesisIEAbiological_process
GO:0090102Cochlea developmentIEAbiological_process
GO:0097084Vascular smooth muscle cell developmentISSbiological_process
GO:0097150Neuronal stem cell maintenanceIEPbiological_process
GO:2000227Negative regulation of pancreatic A cell differentiationIEAbiological_process
GO:2000737Negative regulation of stem cell differentiationIMPbiological_process
GO:2000974Negative regulation of pro-B cell differentiationIMPbiological_process
GO:2000978Negative regulation of forebrain neuron differentiationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06147506170.30790881050.53739126541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8454101600
GSE13712_SHEARUp0.1013144056
GSE13712_STATICUp0.3308316719
GSE19018Down-0.4234182072
GSE19899_A1Up0.2087165967
GSE19899_A2Up0.4129481787
PubMed_21979375_A1Up0.7017144614
PubMed_21979375_A2Up0.7260261354
GSE35957Down-0.9449818231
GSE36640Down-1.0902853502
GSE54402Up0.5787302217
GSE9593Down-0.3888281986
GSE43922Up0.3869268855
GSE24585Up0.4169876073
GSE37065Up0.1060123977
GSE28863_A1Down-0.0133697229
GSE28863_A2Down-0.1805122194
GSE28863_A3Up0.1584674700
GSE28863_A4Up0.0867168450
GSE48662Up0.2582304765

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-199b-5pMIMAT0000263MIRT000208Flow//Immunohistochemistry//In situ hybridization//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19308264
hsa-miR-199b-5pMIMAT0000263MIRT000208Luciferase reporter assayFunctional MTI23354452
hsa-miR-23a-3pMIMAT0000078MIRT002953Immunofluorescence//Luciferase reporter assay//Northern blot//Western blotFunctional MTI12808467
hsa-miR-23a-3pMIMAT0000078MIRT002953Luciferase reporter assayFunctional MTI15066185
hsa-miR-524-5pMIMAT0002849MIRT006893Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22871495
hsa-miR-296-3pMIMAT0004679MIRT038426CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046625CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049494CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051991CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.