HCSGD entry for PRMT2

1. General information

Official gene symbolPRMT2
Entrez ID3275
Gene full nameprotein arginine methyltransferase 2
Other gene symbolsHRMT1L1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006479Protein methylationIEA TASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008168Methyltransferase activityIEAmolecular_function
GO:0008469Histone-arginine N-methyltransferase activityISSmolecular_function
GO:0016274Protein-arginine N-methyltransferase activityISSmolecular_function
GO:0016571Histone methylationIDA ISSbiological_process
GO:0030331Estrogen receptor bindingIDA IPImolecular_function
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0033142Progesterone receptor bindingIPImolecular_function
GO:0034969Histone arginine methylationISSbiological_process
GO:0035189Rb-E2F complexISScellular_component
GO:0035246Peptidyl-arginine N-methylationISSbiological_process
GO:0042054Histone methyltransferase activityIDAmolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0042974Retinoic acid receptor bindingIPImolecular_function
GO:0042975Peroxisome proliferator activated receptor bindingIPImolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046966Thyroid hormone receptor bindingIPImolecular_function
GO:0048588Developmental cell growthISSbiological_process
GO:0050681Androgen receptor bindingIPImolecular_function
GO:0060765Regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0097194Execution phase of apoptosisIDAbiological_process
GO:2000134Negative regulation of G1/S transition of mitotic cell cycleISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93211341890.18481374190.99999024730.8332587359

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1769462400
GSE13712_SHEARUp0.1127610288
GSE13712_STATICDown-0.1156357228
GSE19018Up0.1653434875
GSE19899_A1Down-0.2827744509
GSE19899_A2Up0.0246711234
PubMed_21979375_A1Down-0.4683053907
PubMed_21979375_A2Down-0.3751160603
GSE35957Up0.1273747324
GSE36640Up0.1758457514
GSE54402Down-0.2059276517
GSE9593Up0.2372079492
GSE43922Down-0.2273325651
GSE24585Up0.1575625375
GSE37065Down-0.2335415150
GSE28863_A1Down-0.0244723465
GSE28863_A2Down-0.2159890531
GSE28863_A3Down-0.2695226639
GSE28863_A4Up0.0086079874
GSE48662Up0.2269324153

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-3pMIMAT0000071MIRT050766CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.