HCSGD entry for HPRT1

1. General information

Official gene symbolHPRT1
Entrez ID3251
Gene full namehypoxanthine phosphoribosyltransferase 1
Other gene symbolsHGPRT HPRT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0001975Response to amphetamineIEAbiological_process
GO:0004422Hypoxanthine phosphoribosyltransferase activityEXP IDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIBA TAScellular_component
GO:0006144Purine nucleobase metabolic processTASbiological_process
GO:0006164Purine nucleotide biosynthetic processIMPbiological_process
GO:0006166Purine ribonucleoside salvageIMPbiological_process
GO:0006168Adenine salvageIBAbiological_process
GO:0006178Guanine salvageIDAbiological_process
GO:0007610BehaviorIMPbiological_process
GO:0007625Grooming behaviorIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0019835CytolysisIEAbiological_process
GO:0021756Striatum developmentIEAbiological_process
GO:0021895Cerebral cortex neuron differentiationIEAbiological_process
GO:0021954Central nervous system neuron developmentIEAbiological_process
GO:0032263GMP salvageIBAbiological_process
GO:0032264IMP salvageIBA IEAbiological_process
GO:0042417Dopamine metabolic processIEAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043101Purine-containing compound salvageTASbiological_process
GO:0043103Hypoxanthine salvageIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045964Positive regulation of dopamine metabolic processIMPbiological_process
GO:0046038GMP catabolic processIDAbiological_process
GO:0046040IMP metabolic processIDAbiological_process
GO:0046100Hypoxanthine metabolic processIMPbiological_process
GO:0046651Lymphocyte proliferationIEAbiological_process
GO:0048813Dendrite morphogenesisIEAbiological_process
GO:0051289Protein homotetramerizationIDA IPIbiological_process
GO:0052657Guanine phosphoribosyltransferase activityIDAmolecular_function
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93400090040.06471142050.99999024730.4803353920

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3217981201
GSE13712_SHEARUp0.0584746909
GSE13712_STATICUp0.0827810636
GSE19018Up0.0856746026
GSE19899_A1Down-0.0631015711
GSE19899_A2Down-0.2719254877
PubMed_21979375_A1Up0.3227173540
PubMed_21979375_A2Down-0.1370769162
GSE35957Down-0.4842401245
GSE36640Down-1.0613453988
GSE54402Up0.1760527431
GSE9593Down-0.1102385033
GSE43922Up0.0063166428
GSE24585Down-0.2074005657
GSE37065Down-0.1006995135
GSE28863_A1Down-0.1621361746
GSE28863_A2Down-0.0114268665
GSE28863_A3Down-0.3082114728
GSE28863_A4Up0.2222479195
GSE48662Down-0.7011987466

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AzathioprineDB00993 APRD00811
MercaptopurineDB01033 APRD01096
Alpha-Phosphoribosylpyrophosphoric AcidDB01632 EXPT02663
5--Monophosphate-9-Beta-D-Ribofuranosyl XanthineDB02309 EXPT03260
3h-Pyrazolo[4,3-D]Pyrimidin-7-OlDB03153 EXPT02643
9-DeazaguanineDB04356 EXPT00356

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016412MicroarrayFunctional MTI (Weak)20304954
hsa-miR-34a-5pMIMAT0000255MIRT025379qRT-PCRNon-Functional MTI (Weak)19696787
hsa-miR-30c-5pMIMAT0000244MIRT048012CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22969941Epigallocatechin-3-gallate decreases UVA-induced HPRT mutations in human skin fibroblasts accompanied by increased rates of senescence and apoptosis
22969941Our study was designed to determine the protective effect of epigallocatechin-3-gallate (EGCG) on cultured human skin fibroblasts (HSFs) from multiple ultraviolet A (UVA) irradiation-induced hypoxanthine-guanine phosphoribosyl transferase (HPRT) mutant colony formation and its underlying mechanisms
22969941In our study, the mutation frequency of the HPRT gene was examined by mutagenesis assay
22969941EGCG decreased the UVA-induced HPRT gene mutation frequency by 47
20558399BACKGROUND: Lesch-Nyhan disease is an inborn error of purine metabolism that results from deficiency of the activity of hypoxanthine phosphoribosyltransferase (HPRT)
20558399The heterogeneity of clinical phenotypes seen in HPRT deficiency corresponds to an inverse relationship between HPRT enzyme activity and clinical severity
20558399OBJECTIVE: To document a family in which a single HPRT gene mutation has led to 3 different clinical and enzymatic phenotypes
20558399550G>T in exon 7 of the HPRT gene
17785060OBJECTIVE: To investigate the effects of epigallocatechin-3-gallate (EGCG) on the cell aging and hypoxanthine-phosphoribosyl-transferase (HPRT) gene mutation frequency induced by long-term ultraviolet (UV) A and UVB irradiation in human skin fibroblasts (HSF)
17785060The HPRT gene mutation frequency was detected by the HPRT mutagenesis assay
17785060CONCLUSION: The photo-protection of EGCG on HSFs from long-term UVA and UVB irradiation may be related to both the direct reduction of HPRT mutation frequency and the indirect induction of aging cells, thus decreasing the mutation frequency
12089561Here we have used AAV vectors to introduce large (>1 kb) functional transgene cassettes into the hypoxanthine phosphoribosyl transferase (HPRT) and Type I collagen (COL1A1) loci in normal human fibroblasts
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