HCSGD entry for APC

1. General information

Official gene symbolAPC
Entrez ID324
Gene full nameadenomatous polyposis coli
Other gene symbolsBTPS2 DP2 DP2.5 DP3 GS PPP1R46
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000281Mitotic cytokinesisIEA IMPbiological_process
GO:0000776KinetochoreIDAcellular_component
GO:0001822Kidney developmentIEAbiological_process
GO:0001942Hair follicle developmentIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005881Cytoplasmic microtubuleIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005913Cell-cell adherens junctionIDAcellular_component
GO:0005923Tight junctionIDAcellular_component
GO:0006461Protein complex assemblyIDAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0006974Cellular response to DNA damage stimulusIDA IEAbiological_process
GO:0007026Negative regulation of microtubule depolymerizationIDA IEA IMPbiological_process
GO:0007050Cell cycle arrestIDA IEAbiological_process
GO:0007091Metaphase/anaphase transition of mitotic cell cycleIEAbiological_process
GO:0007094Mitotic spindle assembly checkpointIMPbiological_process
GO:0007155Cell adhesionNASbiological_process
GO:0007409AxonogenesisIEAbiological_process
GO:0008013Beta-catenin bindingIEA IPImolecular_function
GO:0008017Microtubule bindingIDAmolecular_function
GO:0008285Negative regulation of cell proliferationIDA IEAbiological_process
GO:0009798Axis specificationIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0009953Dorsal/ventral pattern formationIEAbiological_process
GO:0009954Proximal/distal pattern formationIEAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016328Lateral plasma membraneIDAcellular_component
GO:0016477Cell migrationIEA IMPbiological_process
GO:0019887Protein kinase regulator activityIDAmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030027LamellipodiumIDAcellular_component
GO:0030178Negative regulation of Wnt signaling pathwayIEAbiological_process
GO:0030335Positive regulation of cell migrationIEA IMPbiological_process
GO:0030858Positive regulation of epithelial cell differentiationIEAbiological_process
GO:0030877Beta-catenin destruction complexIDAcellular_component
GO:0031116Positive regulation of microtubule polymerizationIEAbiological_process
GO:0031122Cytoplasmic microtubule organizationIEAbiological_process
GO:0031253Cell projection membraneIEAcellular_component
GO:0031274Positive regulation of pseudopodium assemblyIMPbiological_process
GO:0032587Ruffle membraneIDAcellular_component
GO:0032886Regulation of microtubule-based processIMPbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0035371Microtubule plus-endIEAcellular_component
GO:0042483Negative regulation of odontogenesisIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEA IMPbiological_process
GO:0043409Negative regulation of MAPK cascadeIEAbiological_process
GO:0044295Axonal growth coneIEAcellular_component
GO:0044336Canonical Wnt signaling pathway involved in negative regulation of apoptotic processIEAbiological_process
GO:0044337Canonical Wnt signaling pathway involved in positive regulation of apoptotic processIEAbiological_process
GO:0045295Gamma-catenin bindingIPImolecular_function
GO:0045296Cadherin bindingIDAmolecular_function
GO:0045667Regulation of osteoblast differentiationIEAbiological_process
GO:0045670Regulation of osteoclast differentiationIEAbiological_process
GO:0045732Positive regulation of protein catabolic processIC IEA IGIbiological_process
GO:0045736Negative regulation of cyclin-dependent protein serine/threonine kinase activityIDAbiological_process
GO:0045785Positive regulation of cell adhesionIEAbiological_process
GO:0046716Muscle cell cellular homeostasisIEAbiological_process
GO:0048538Thymus developmentIEAbiological_process
GO:0051010Microtubule plus-end bindingIDA IEAmolecular_function
GO:0051171Regulation of nitrogen compound metabolic processIEAbiological_process
GO:0051276Chromosome organizationIEAbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0051988Regulation of attachment of spindle microtubules to kinetochoreIEA IMP NASbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIC NASbiological_process
GO:0060770Negative regulation of epithelial cell proliferation involved in prostate gland developmentIEAbiological_process
GO:0070830Tight junction assemblyNASbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEA IGIbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.21674212610.59935679500.89567947951.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0675557909
GSE13712_SHEARUp0.2124516051
GSE13712_STATICUp0.2873076228
GSE19018Up0.1885703497
GSE19899_A1Up0.1810979968
GSE19899_A2Down-0.1765134107
PubMed_21979375_A1Up0.3206622182
PubMed_21979375_A2Up0.2477242802
GSE35957Up0.4137686836
GSE36640Up0.7948142940
GSE54402Down-0.1316294337
GSE9593Up0.0285994565
GSE43922Down-0.0463220394
GSE24585Down-0.0388560283
GSE37065Down-0.0103728516
GSE28863_A1Down-0.3934414079
GSE28863_A2Up0.2102919673
GSE28863_A3Down-0.9681045639
GSE28863_A4Down-0.0526221304
GSE48662Up0.2959743414

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT001207Luciferase reporter assay//Western blotFunctional MTI19136465
hsa-miR-155-5pMIMAT0000646MIRT001207ProteomicsFunctional MTI (Weak)20584899
hsa-miR-27a-3pMIMAT0000084MIRT006221Luciferase reporter assay//Western blotFunctional MTI22018270
hsa-miR-210-3pMIMAT0000267MIRT003183immunoprecipitaion//Microarray//qRT-PCRFunctional MTI (Weak)19826008
hsa-miR-106b-5pMIMAT0000680MIRT007071Flow//Immunofluorescence//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23087084
hsa-miR-215-5pMIMAT0000272MIRT024577MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026886MicroarrayFunctional MTI (Weak)19074876
hsa-miR-21-5pMIMAT0000076MIRT031054MicroarrayFunctional MTI (Weak)18591254
hsa-miR-186-5pMIMAT0000456MIRT045069CLASHFunctional MTI (Weak)23622248
hsa-miR-148a-3pMIMAT0000243MIRT048033CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24910096This mitosis skip is mediated by both p53-dependent premature activation of APC/C(Cdh1) and pRb family protein-dependent transcriptional suppression of mitotic regulators
22178396DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells
22178396These findings establish a role for APC/C(Cdh1) and reveal how the DDR integrates with epigenetic processes to induce senescence-associated gene expression
21241890Here we show that nuclear PTEN interacts with APC/C, promotes APC/C association with CDH1, and thereby enhances the tumor-suppressive activity of the APC-CDH1 complex
21191073We determined cell senescence, intracellular cytokine expression, ability to interact with endothelial cells, and APC activity
19693768Fifteen cell-cycle regulator genes were investigated and only three genes (APC, CCND2, and BMP2) were differentially expressed between bMSC and oMSC
17875940Expression of the anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 is required for the accumulation of APC/C substrates crucial for DNA synthesis and mitotic entry
17875940Emi1 depletion leads to strong decreases in E2F target mRNA and APC/C substrate protein abundances
17643075It is mediated by checkpoint complexes or individual proteins that inhibit the ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C) via targeting of the Cdc20 regulatory subunit
14728717N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA
14728717We then examined a possible association of the expression of APC protein and telomeric DNA signals with cellular senescence in MNNG-treated cells
14728717We found that protein and mRNA levels of APC were drastically reduced in cells treated with higher concentrations of MNNG
14728717The loss of APC expression might lead to chromosomal instability as well as microtubular disorganization through its dissociation with tubulin
14728717CONCLUSIONS: These results suggest that in response to DNA alkylation damage the senescence-like arrest of HCT-116 cells was associated with decreased levels of APC protein, microtubular organization, and telomeric DNA
11991846As antigen presenting cell (APC) function appears to be well-maintained in the elderly, this review will focus on the T cell
11280772The majority of colonic neoplasias contain mutations in either the adenomatous polyposis coli or the beta-catenin (beta-cat) gene, both of which result in elevated levels of cytoplasmic beta-cat
11280772Stable beta-cat-expressing populations could not be generated in conditionally immortalized colonic epithelia cells with a wild-type Apc background
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