HCSGD entry for APBB2
1. General information
| Official gene symbol | APBB2 |
|---|---|
| Entrez ID | 323 |
| Gene full name | amyloid beta (A4) precursor protein-binding, family B, member 2 |
| Other gene symbols | FE65L FE65L1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001540 | Beta-amyloid binding | ISS | molecular_function |
| GO:0001764 | Neuron migration | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA ISS | biological_process |
| GO:0007050 | Cell cycle arrest | IEA ISS | biological_process |
| GO:0007411 | Axon guidance | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IEA ISS | molecular_function |
| GO:0016020 | Membrane | NAS | cellular_component |
| GO:0030027 | Lamellipodium | ISS | cellular_component |
| GO:0030198 | Extracellular matrix organization | IEA | biological_process |
| GO:0030308 | Negative regulation of cell growth | IEA ISS | biological_process |
| GO:0030426 | Growth cone | ISS | cellular_component |
| GO:0035556 | Intracellular signal transduction | NAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0045202 | Synapse | ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1777432658 | 0.7435493674 | 0.8267150557 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3093506489 |
| GSE13712_SHEAR | Up | 0.1775797682 |
| GSE13712_STATIC | Up | 0.2215076629 |
| GSE19018 | Up | 0.3893977008 |
| GSE19899_A1 | Up | 0.0226819902 |
| GSE19899_A2 | Up | 0.0601635020 |
| PubMed_21979375_A1 | Up | 0.1367872116 |
| PubMed_21979375_A2 | Up | 0.3815353314 |
| GSE35957 | Up | 0.1735247158 |
| GSE36640 | Up | 0.4757276278 |
| GSE54402 | Down | -0.3368835211 |
| GSE9593 | Up | 0.3122441996 |
| GSE43922 | Down | -0.0515164475 |
| GSE24585 | Down | -0.0443180926 |
| GSE37065 | Down | -0.0151543129 |
| GSE28863_A1 | Up | 0.1465268820 |
| GSE28863_A2 | Up | 0.3350054978 |
| GSE28863_A3 | Down | -0.1202187421 |
| GSE28863_A4 | Down | -0.0481530920 |
| GSE48662 | Up | 0.1920866030 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016918 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019283 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021359 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028935 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT042448 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048805 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT050013 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052766 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
