HCSGD entry for HOXB4
1. General information
| Official gene symbol | HOXB4 |
|---|---|
| Entrez ID | 3214 |
| Gene full name | homeobox B4 |
| Other gene symbols | HOX-2.6 HOX2 HOX2F |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0002011 | Morphogenesis of an epithelial sheet | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0048103 | Somatic stem cell division | IEA | biological_process |
| GO:0048536 | Spleen development | IEA | biological_process |
| GO:0048539 | Bone marrow development | IEA | biological_process |
| GO:0048704 | Embryonic skeletal system morphogenesis | IEA | biological_process |
| GO:0060216 | Definitive hemopoiesis | IEA | biological_process |
| GO:0060218 | Hematopoietic stem cell differentiation | IDA | biological_process |
| GO:2000738 | Positive regulation of stem cell differentiation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7405421944 | 0.0239470993 | 0.9999902473 | 0.2981606433 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0832822854 |
| GSE13712_SHEAR | Up | 0.3488189484 |
| GSE13712_STATIC | Up | 0.2077661600 |
| GSE19018 | Up | 0.0561363316 |
| GSE19899_A1 | Down | -0.4161696926 |
| GSE19899_A2 | Down | -0.2850269449 |
| PubMed_21979375_A1 | Down | -2.5914232868 |
| PubMed_21979375_A2 | Down | -0.8141832915 |
| GSE35957 | Down | -0.5926657139 |
| GSE36640 | Down | -0.9552133572 |
| GSE54402 | Down | -0.3619121778 |
| GSE9593 | Up | 0.0471832295 |
| GSE43922 | Down | -0.4577245218 |
| GSE24585 | Up | 0.8932021598 |
| GSE37065 | Down | -0.0356123931 |
| GSE28863_A1 | Down | -0.1709384645 |
| GSE28863_A2 | Down | -0.2289935234 |
| GSE28863_A3 | Up | 0.1991337544 |
| GSE28863_A4 | Up | 0.0848347625 |
| GSE48662 | Down | -0.2090800479 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7a-5p | MIMAT0000062 | MIRT052567 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21198398 | The increase in HSC expansion is likely attributable to SB-mediated inhibition of HSC apoptosis and senescence and upregulation of HoxB4 and CXCR4 |
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