HCSGD entry for HOXA5
1. General information
| Official gene symbol | HOXA5 |
|---|---|
| Entrez ID | 3202 |
| Gene full name | homeobox A5 |
| Other gene symbols | HOX1 HOX1.3 HOX1C |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003016 | Respiratory system process | IEA | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0010870 | Positive regulation of receptor biosynthetic process | IDA | biological_process |
| GO:0016477 | Cell migration | IEA | biological_process |
| GO:0016525 | Negative regulation of angiogenesis | IMP | biological_process |
| GO:0030878 | Thyroid gland development | IEA | biological_process |
| GO:0033599 | Regulation of mammary gland epithelial cell proliferation | IEA | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IDA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045639 | Positive regulation of myeloid cell differentiation | IDA | biological_process |
| GO:0045647 | Negative regulation of erythrocyte differentiation | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0048286 | Lung alveolus development | IEA | biological_process |
| GO:0048704 | Embryonic skeletal system morphogenesis | IEA | biological_process |
| GO:0060435 | Bronchiole development | IEA | biological_process |
| GO:0060441 | Epithelial tube branching involved in lung morphogenesis | IEA | biological_process |
| GO:0060480 | Lung goblet cell differentiation | IEA | biological_process |
| GO:0060484 | Lung-associated mesenchyme development | IEA | biological_process |
| GO:0060535 | Trachea cartilage morphogenesis | IEA | biological_process |
| GO:0060574 | Intestinal epithelial cell maturation | IEA | biological_process |
| GO:0060638 | Mesenchymal-epithelial cell signaling | IEA | biological_process |
| GO:0060644 | Mammary gland epithelial cell differentiation | IEA | biological_process |
| GO:0060749 | Mammary gland alveolus development | IEA | biological_process |
| GO:0060764 | Cell-cell signaling involved in mammary gland development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4751116485 | 0.0006040196 | 0.9999902473 | 0.0463510204 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1554676384 |
| GSE13712_SHEAR | Down | -0.7266621309 |
| GSE13712_STATIC | Down | -0.6165513040 |
| GSE19018 | Up | 0.0466987390 |
| GSE19899_A1 | Down | -2.3912591234 |
| GSE19899_A2 | Down | -2.3460073452 |
| PubMed_21979375_A1 | Down | -2.2362746817 |
| PubMed_21979375_A2 | Down | -3.1526602565 |
| GSE35957 | Down | -1.1938983146 |
| GSE36640 | Down | -2.9476277808 |
| GSE54402 | Down | -1.2667551969 |
| GSE9593 | Down | -0.3969886283 |
| GSE43922 | Down | -1.0297608934 |
| GSE24585 | Up | 1.7054830017 |
| GSE37065 | Up | 0.1508209355 |
| GSE28863_A1 | Up | 0.3140876661 |
| GSE28863_A2 | Up | 0.7488712520 |
| GSE28863_A3 | Down | -0.2166736858 |
| GSE28863_A4 | Down | -0.0635138320 |
| GSE48662 | Up | 0.4013272316 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130a-3p | MIMAT0000425 | MIRT000958 | Luciferase reporter assay//qRT-PCR//Western blot//Northern blot//Reporter assay;Other | Functional MTI | 17957028 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT001794 | Luciferase reporter assay | Functional MTI | 14697198 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT001794 | Reporter assay;Other | Non-Functional MTI | 21271217 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT006906 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22876840 |
| hsa-miR-374b-5p | MIMAT0004955 | MIRT016043 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-484 | MIMAT0002174 | MIRT016627 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019581 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020201 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT025008 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031182 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049277 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-130a-3p | MIMAT0000425 | NA | hsa-miR-130a | {Western blot} | {overexpression} | 17957028 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
