HCSGD entry for TLX2
1. General information
| Official gene symbol | TLX2 |
|---|---|
| Entrez ID | 3196 |
| Gene full name | T-cell leukemia homeobox 2 |
| Other gene symbols | HOX11L1 NCX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001707 | Mesoderm formation | IEA | biological_process |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0048484 | Enteric nervous system development | IEA | biological_process |
| GO:0050774 | Negative regulation of dendrite morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4900591239 | 0.8201829832 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0276697441 |
| GSE13712_SHEAR | Down | -0.0137783010 |
| GSE13712_STATIC | Up | 0.0817451029 |
| GSE19018 | Up | 0.1646630548 |
| GSE19899_A1 | Down | -0.0910738225 |
| GSE19899_A2 | Up | 0.0973382446 |
| PubMed_21979375_A1 | Down | -0.2800543781 |
| PubMed_21979375_A2 | Down | -0.0289024442 |
| GSE35957 | Down | -0.0810630809 |
| GSE36640 | Up | 0.0568219029 |
| GSE54402 | Up | 0.0175106490 |
| GSE9593 | Up | 0.1413495819 |
| GSE43922 | Up | 0.2100707275 |
| GSE24585 | Up | 0.1629496001 |
| GSE37065 | Down | -0.0578146765 |
| GSE28863_A1 | Down | -0.1167519795 |
| GSE28863_A2 | Down | -0.1194922285 |
| GSE28863_A3 | Up | 0.4248641722 |
| GSE28863_A4 | Up | 0.0890446759 |
| GSE48662 | Down | -0.0357909396 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21486281 | Here, we investigated if the NO-donating atorvastatin (NCX 547) improved the functions of circulating angiogenic cells (CACs) |
| 21486281 | EXPERIMENTAL APPROACH: Circulating angiogenic cells (CACs) were prepared from peripheral blood monocytes of healthy volunteers and type-2 diabetic patients and were cultured in low (LG) or high glucose (HG) conditions, in presence of atorvastatin or NCX 547 (both at 0 |
| 21486281 | NCX 547 fully restored NO levels and functions of HG-cultured CACs, while atorvastatin prevented only apoptosis in CACs |
| 21486281 | The activity of Akt, a pro-survival kinase, was increased by atorvastatin in LG-cultured but not in HG-cultured CACs, whereas NCX 547 increased Akt activity in both conditions |
| 21486281 | L-NIO partially blunted and c-PTIO prevented NCX 547-induced improvements in CAC functions |
| 21486281 | Finally, NCX 547 improved outgrowth and migration of CACs prepared from patients with type 2 diabetes |
| 21486281 | CONCLUSIONS AND IMPLICATIONS: NCX 547 was more effective than atorvastatin in preserving functions of CACs |
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