HCSGD entry for TLX1
1. General information
| Official gene symbol | TLX1 |
|---|---|
| Entrez ID | 3195 |
| Gene full name | T-cell leukemia homeobox 1 |
| Other gene symbols | HOX11 TCL3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0007417 | Central nervous system development | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0030182 | Neuron differentiation | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045165 | Cell fate commitment | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0048536 | Spleen development | IEA | biological_process |
| GO:0048645 | Organ formation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8043459481 | 0.3901084723 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0076289506 |
| GSE13712_SHEAR | Down | -0.1188416014 |
| GSE13712_STATIC | Down | -0.0749839478 |
| GSE19018 | Down | -0.0398888085 |
| GSE19899_A1 | Down | -0.1177208974 |
| GSE19899_A2 | Down | -0.0463518902 |
| PubMed_21979375_A1 | Up | 0.0166585831 |
| PubMed_21979375_A2 | Down | -0.2736409165 |
| GSE35957 | Up | 0.1744367855 |
| GSE36640 | Down | -0.0240994625 |
| GSE54402 | Up | 0.0893792705 |
| GSE9593 | Up | 0.1006114776 |
| GSE43922 | Up | 0.0373437733 |
| GSE24585 | Down | -0.5666748699 |
| GSE37065 | Down | -0.0864856409 |
| GSE28863_A1 | Down | -0.0762294306 |
| GSE28863_A2 | Down | -0.0473493339 |
| GSE28863_A3 | Up | 0.4020660880 |
| GSE28863_A4 | Up | 0.1125287849 |
| GSE48662 | Up | 0.0476568863 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-340-5p | MIMAT0004692 | MIRT019615 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029889 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
