HCSGD entry for HNRNPU
1. General information
| Official gene symbol | HNRNPU |
|---|---|
| Entrez ID | 3192 |
| Gene full name | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) |
| Other gene symbols | HNRPU SAF-A U21.1 hnRNP U |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000398 | MRNA splicing, via spliceosome | IC TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0070934 | CRD-mediated mRNA stabilization | IMP | biological_process |
| GO:0070937 | CRD-mediated mRNA stability complex | IDA | cellular_component |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9224962995 | 0.0520934311 | 0.9999902473 | 0.4294325399 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0748945347 |
| GSE13712_SHEAR | Up | 0.0947097870 |
| GSE13712_STATIC | Up | 0.0248908783 |
| GSE19018 | Down | -0.4385264290 |
| GSE19899_A1 | Down | -0.2239179422 |
| GSE19899_A2 | Down | -0.5331607262 |
| PubMed_21979375_A1 | Down | -0.1936189004 |
| PubMed_21979375_A2 | Down | -0.5534359913 |
| GSE35957 | Down | -0.2370975705 |
| GSE36640 | Down | -0.9189788556 |
| GSE54402 | Down | -0.0339001596 |
| GSE9593 | Down | -0.2366835882 |
| GSE43922 | Down | -0.0702857208 |
| GSE24585 | Down | -0.0471518093 |
| GSE37065 | Down | -0.0586359241 |
| GSE28863_A1 | Up | 0.4869202500 |
| GSE28863_A2 | Up | 0.0404716264 |
| GSE28863_A3 | Up | 0.3476436725 |
| GSE28863_A4 | Up | 0.0843962525 |
| GSE48662 | Down | -0.4373232947 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT005282 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025868 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039706 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045256 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045483 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046200 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047974 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050141 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050837 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25406515 | Here we demonstrate that scaffold-attachment-factor A (SAFA) and the long noncoding RNA PANDA differentially interact with polycomb repressive complexes (PRC1 and PRC2) and the transcription factor NF-YA to either promote or suppress senescence |
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