HCSGD entry for HNF4A

1. General information

Official gene symbolHNF4A
Entrez ID3172
Gene full namehepatocyte nuclear factor 4, alpha
Other gene symbolsHNF4 HNF4a7 HNF4a8 HNF4a9 HNF4alpha MODY MODY1 NR2A1 NR2A21 TCF TCF14
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingISSmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0005102Receptor bindingIDAmolecular_function
GO:0005504Fatty acid bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006591Ornithine metabolic processIMPbiological_process
GO:0006629Lipid metabolic processIEAbiological_process
GO:0006805Xenobiotic metabolic processIMPbiological_process
GO:0007548Sex differentiationIEAbiological_process
GO:0007596Blood coagulationIDAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0009749Response to glucoseISSbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010470Regulation of gastrulationIEAbiological_process
GO:0019216Regulation of lipid metabolic processIDAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030308Negative regulation of cell growthIMPbiological_process
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0050796Regulation of insulin secretionISSbiological_process
GO:0055088Lipid homeostasisIMPbiological_process
GO:0055091Phospholipid homeostasisISSbiological_process
GO:0060395SMAD protein signal transductionIEAbiological_process
GO:0060398Regulation of growth hormone receptor signaling pathwayNASbiological_process
GO:0070328Triglyceride homeostasisISSbiological_process
GO:2000189Positive regulation of cholesterol homeostasisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84153175790.79506217470.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0228037961
GSE13712_SHEARUp0.0080599569
GSE13712_STATICDown-0.0255419893
GSE19018Up0.0526191976
GSE19899_A1Up0.0198562344
GSE19899_A2Up0.0388504583
PubMed_21979375_A1Down-0.0150706365
PubMed_21979375_A2Down-0.1163407867
GSE35957Up0.0834453150
GSE36640Up0.0692349592
GSE54402Up0.0539891955
GSE9593Down-0.0148171446
GSE43922Up0.0899632512
GSE24585Down-0.0721876565
GSE37065Down-0.0502732564
GSE28863_A1Down-0.1296494749
GSE28863_A2Down-0.2386453195
GSE28863_A3Up0.2933345685
GSE28863_A4Up0.1081779345
GSE48662Up0.0162428727

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AVI-4557DB05447 -
MYRISTIC ACIDDB08231 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-765MIMAT0003945MIRT006266Luciferase reporter assayFunctional MTI22232426
hsa-miR-34b-5pMIMAT0000685MIRT006265Luciferase reporter assayFunctional MTI22232426
hsa-miR-34c-5pMIMAT0000686MIRT006263Luciferase reporter assayFunctional MTI22232426
hsa-miR-449aMIMAT0001541MIRT006262Luciferase reporter assay//Western blotFunctional MTI22232426
hsa-miR-34a-5pMIMAT0000255MIRT003356Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20018894
hsa-miR-34a-5pMIMAT0000255MIRT003356Luciferase reporter assay//Western blotFunctional MTI22232426
hsa-miR-24-3pMIMAT0000080MIRT003355Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20018894
hsa-miR-24-3pMIMAT0000080MIRT003355ELISA//Flow//Immunohistochemistry//Immunoprecipitaion//In situ hybridization//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI22153071
hsa-miR-629-5pMIMAT0004810MIRT006542ELISA//Flow//Immunohistochemistry//Immunoprecipitaion//In situ hybridization//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI22153071
hsa-miR-197-3pMIMAT0000227MIRT003822MicroarrayFunctional MTI (Weak)16822819
hsa-miR-766-3pMIMAT0003888MIRT006264Luciferase reporter assayNon-Functional MTI22232426
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27698927As with those evidence of senescence in advanced cell passages, expression of p21 and cyclin D1 increased when the expression of beta-catenin and its downstream protein, TCF, declined
27358050LATS-YAP/TAZ controls lineage specification by regulating TGFbeta signaling and Hnf4alpha expression during liver development
27358050It increases BEC and fibroblast proliferation by up-regulating TGFbeta signalling, but suppresses hepatoblast to hepatocyte differentiation by repressing Hnf4alpha expression
22767186Furthermore, we used glutathione S-transferase pull-down, co-immunoprecipitation, and confocal microscopy to demonstrate that SOX1 could interact with beta-catenin but not with the beta-catenin/TCF complex
18925631Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene
18925631UNLABELLED: Previous studies have shown that hepatocyte nuclear factor-4alpha (HNF4alpha) is a central regulator of differentiated hepatocyte phenotype and forced expression of HNF4alpha could promote reversion of tumors toward a less invasive phenotype
18925631In this study, an adenovirus-mediated gene delivery system, which could efficiently transfer and express HNF4alpha, was generated to determine its effect on hepatoma cells (Hep3B and HepG2) in vitro and investigate the anti-tumor effect of HNF4alpha in mice
18925631Moreover, infection of hepatoma cells by HNF4alpha abolished their tumorigenesis in mice
18925631Most interestingly, systemic administration of adenovirus carrying the HNF4alpha gene protected mice from liver metastatic tumor formation, and intratumoral injection of HNF4alpha also displayed significant antitumor effects on transplanted tumor models
12470826Transcription of c-fos in response to mitogens depends on the activation of a multiprotein complex formed on the c-fos serum response element (SRE), which includes the transcription factors serum response factor (SRF) and ternary complex factor (TCF)
12470826TCF is activated after phosphorylation by the Extracellular signals Regulated Kinase 1 and 2 (ERK1/2), two kinases of the Raf/MEK/ERK signaling pathway
11570821Transcription of c-fos in response to mitogens depends on the activation of a multiprotein complex formed on the c-fos serum response element (SRE), which includes the transcription factors SRF (serum response factor) and TCF (ternary complex factor)
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