HCSGD entry for FOXA1

1. General information

Official gene symbolFOXA1
Entrez ID3169
Gene full nameforkhead box A1
Other gene symbolsHNF3A TCF3A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0003690Double-stranded DNA bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA TASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIBAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0006338Chromatin remodelingIEA ISSbiological_process
GO:0006366Transcription from RNA polymerase II promoterIBA ISSbiological_process
GO:0007389Pattern specification processIBAbiological_process
GO:0008134Transcription factor bindingIBA IEAmolecular_function
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0009790Embryo developmentIBAbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021904Dorsal/ventral neural tube patterningIEAbiological_process
GO:0032355Response to estradiolIDAbiological_process
GO:0033148Positive regulation of intracellular estrogen receptor signaling pathwayIMPbiological_process
GO:0042445Hormone metabolic processIEAbiological_process
GO:0042593Glucose homeostasisIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045880Positive regulation of smoothened signaling pathwayIEAbiological_process
GO:0045931Positive regulation of mitotic cell cycleIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEA IMPbiological_process
GO:0048646Anatomical structure formation involved in morphogenesisIEAbiological_process
GO:0048665Neuron fate specificationIBA IEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0051726Regulation of cell cycleIEAbiological_process
GO:0060441Epithelial tube branching involved in lung morphogenesisIEAbiological_process
GO:0060487Lung epithelial cell differentiationIEAbiological_process
GO:0060528Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus developmentIBA IEAbiological_process
GO:0060738Epithelial-mesenchymal signaling involved in prostate gland developmentIBA IEAbiological_process
GO:0060740Prostate gland epithelium morphogenesisIBA IEAbiological_process
GO:0060741Prostate gland stromal morphogenesisIBA IEAbiological_process
GO:0060743Epithelial cell maturation involved in prostate gland developmentIBA IEAbiological_process
GO:2000049Positive regulation of cell-cell adhesion mediated by cadherinICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07677944230.95700792900.58579991311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1530795486
GSE13712_SHEARUp1.2749589774
GSE13712_STATICUp1.0625074337
GSE19018Up0.2036102518
GSE19899_A1Up0.0535028141
GSE19899_A2Down-0.0707103878
PubMed_21979375_A1Up0.0487549614
PubMed_21979375_A2Down-0.0298067860
GSE35957Up0.1373426569
GSE36640Up0.3979848598
GSE54402Down-0.0018915719
GSE9593Down-0.1327125644
GSE43922Up0.2278132900
GSE24585Up0.5437002441
GSE37065Down-0.0764873684
GSE28863_A1Down-0.0557015933
GSE28863_A2Up0.0748464121
GSE28863_A3Up0.2609021162
GSE28863_A4Up0.1073340163
GSE48662Down-0.0156561930

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7a-5pMIMAT0000062MIRT002078Luciferase reporter assayNon-Functional MTI17890240
hsa-miR-215-5pMIMAT0000272MIRT024644MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026509MicroarrayFunctional MTI (Weak)19074876
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27349269We previously identified FOXA1 as a tumor-suppressor in EC cells
27349269In the present study, we sought to delineate the different roles of FOXA1 associated with cell senescence and further investigated the correlation between FOXA1 and p16INK4a in the progression of EC
27349269Using reverse transcription-quantitative PCR (RT-qPCR), we found that FOXA1 expression was significantly downregulated in EC cells compared to that in normal endometrial cells
27349269Functionally, senescenceassociated beta-galactosidase staining, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), clonogenic and Transwell assays showed that in addition to acting as a pioneer factor, FOXA1 was significantly upregulated in senescent EC cells
27349269Furthermore, restoration of FOXA1 expression triggered multiple steps of cellular senescence in EC cells and activated p16INK4a expression
25264199Our recent investigations revealed that FOXA1 as a forkhead transcription factor mediates CDKN2A activation in cellular senescence
25264199Here, using a comprehensive collection of cancer microarray data, we found FOXA1 is down-regulated in many cancers compared to their normal counterparts and the positive correlation between FOXA1 and CDKN2A could be observed in prostate and breast cancers with lower EZH2 (epigenetic repressor for CDKN2A) expression
25264199Experimentally, epistasis analysis in prostate and breast cancer cells indicated that higher expression of FOXA1 opposes EZH2-mediated CDKN2A repression, as further depletion of FOXA1 reverts the de-silencing of CDKN2A caused by EZH2 inhibition
25264199Concomitantly, EZH2-depletion suppresses cancer cell cycle progression and this regulation is optimized in the presence of FOXA1 and CDKN2A
25264199A further oncogenic transformation assay suggested that overexpression of EZH2 is insufficient to block RAS-induced CDKN2A activation and loss of FOXA1 is mandatory to potentiate EZH2-mediated CDKN2A silencing and to bypass the senescence barrier
25264199Importantly, using an in vitro histone methyltransferase (HMTase) system, we found FOXA1 directly inhibits EZH2's histone methyltransferase activity through its C-terminal histone binding motif
25264199These data support that positive regulation of CDKN2A by FOXA1 counteracts its tumorigenic repression of by EZH2 in cancers
23443045Here, we report that Forkhead box A1 protein (FOXA1) is significantly upregulated in both replicative and oncogene-induced senescence, and in turn activates transcription of p16(INK4a) through multiple mechanisms
23443045In addition to acting as a classic sequence-specific transcriptional activator, FOXA1 binding leads to a decrease in nucleosome density at the p16(INK4a) promoter in senescent fibroblasts
23443045Moreover, FOXA1, itself a direct target of Polycomb-mediated repression, antagonizes Polycomb function at the p16(INK4a) locus
23443045Finally, a systematic survey of putative FOXA1 binding sites in the p16(INK4a) genomic region revealed an approximately 150 kb distal element that could loop back to the promoter and potentiate p16(INK4a) expression
23443045Overall, our findings establish several mechanisms by which FOXA1 controls p16(INK4a) expression during cellular senescence
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