HCSGD entry for HMX2
1. General information
| Official gene symbol | HMX2 |
|---|---|
| Entrez ID | 3167 |
| Gene full name | H6 family homeobox 2 |
| Other gene symbols | H6L Nkx5-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0042472 | Inner ear morphogenesis | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4213778504 | 0.8165504464 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1001786332 |
| GSE13712_SHEAR | Down | -0.0617413118 |
| GSE13712_STATIC | Down | -0.2246485345 |
| GSE19018 | Up | 0.0745845334 |
| GSE19899_A1 | Down | -0.1242115242 |
| GSE19899_A2 | Up | 0.0817695977 |
| PubMed_21979375_A1 | Up | 0.0906314124 |
| PubMed_21979375_A2 | Up | 0.0135887825 |
| GSE35957 | Up | 0.1080788451 |
| GSE36640 | Up | 0.0864968413 |
| GSE54402 | Down | -0.1029644248 |
| GSE9593 | Down | -0.0254048834 |
| GSE43922 | Up | 0.1536952359 |
| GSE24585 | Up | 0.0796184310 |
| GSE37065 | Down | -0.0637474298 |
| GSE28863_A1 | Up | 0.0254674514 |
| GSE28863_A2 | Up | 0.0104995128 |
| GSE28863_A3 | Up | 0.4573087651 |
| GSE28863_A4 | Up | 0.1496479449 |
| GSE48662 | Up | 0.2912611633 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21047732 | The transcription factor orthodenticle homeobox 2 (OTX2) has been implicated in the pathogenesis of medulloblastoma, as it is often highly expressed and sometimes amplified in these tumors |
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