HCSGD entry for HMGA1
1. General information
| Official gene symbol | HMGA1 |
|---|---|
| Entrez ID | 3159 |
| Gene full name | high mobility group AT-hook 1 |
| Other gene symbols | HMG-R HMGA1A HMGIY |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000785 | Chromatin | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA TAS | molecular_function |
| GO:0003680 | AT DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IMP | molecular_function |
| GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006268 | DNA unwinding involved in DNA replication | NAS | biological_process |
| GO:0006284 | Base-excision repair | IDA | biological_process |
| GO:0006337 | Nucleosome disassembly | TAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA TAS | biological_process |
| GO:0006461 | Protein complex assembly | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IDA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IMP | biological_process |
| GO:0009615 | Response to virus | IEP | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | IMP | molecular_function |
| GO:0031936 | Negative regulation of chromatin silencing | TAS | biological_process |
| GO:0035985 | Senescence-associated heterochromatin focus | IDA | cellular_component |
| GO:0035986 | Senescence-associated heterochromatin focus assembly | IDA | biological_process |
| GO:0042974 | Retinoic acid receptor binding | IDA | molecular_function |
| GO:0042975 | Peroxisome proliferator activated receptor binding | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0046965 | Retinoid X receptor binding | IDA | molecular_function |
| GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity | IDA | molecular_function |
| GO:0075713 | Establishment of integrated proviral latency | TAS | biological_process |
| GO:0090402 | Oncogene-induced cell senescence | IDA | biological_process |
| GO:2000774 | Positive regulation of cellular senescence | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0521424908 | 0.1992065005 | 0.5002105780 | 0.8633812449 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6469805800 |
| GSE13712_SHEAR | Up | 0.5494517968 |
| GSE13712_STATIC | Up | 0.2063719081 |
| GSE19018 | Up | 0.2897139451 |
| GSE19899_A1 | Up | 0.0906185552 |
| GSE19899_A2 | Up | 0.3816799841 |
| PubMed_21979375_A1 | Up | 0.3496051485 |
| PubMed_21979375_A2 | Down | -0.9221785035 |
| GSE35957 | Down | -0.6623409347 |
| GSE36640 | Down | -0.2814390141 |
| GSE54402 | Up | 0.4183359376 |
| GSE9593 | Up | 0.4350394029 |
| GSE43922 | Down | -0.0160039233 |
| GSE24585 | Down | -0.3489094396 |
| GSE37065 | Up | 0.1726406572 |
| GSE28863_A1 | Down | -0.1621404126 |
| GSE28863_A2 | Up | 0.1060924803 |
| GSE28863_A3 | Up | 0.3755451705 |
| GSE28863_A4 | Up | 0.0178064526 |
| GSE48662 | Down | -0.7079324359 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26a-5p | MIMAT0000082 | MIRT000110 | Luciferase reporter assay | Functional MTI | 17563749 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT000110 | Luciferase reporter assay//Western blot | Functional MTI | 22245693 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT000270 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19250063 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT000349 | Luciferase reporter assay | Functional MTI | 17563749 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT001625 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT001625 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT006562 | Flow//Immunohistochemistry//Immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 22249617 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT003152 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19179606 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT003152 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018872 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027852 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035976 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037176 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037370 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037580 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038421 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039276 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040930 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042853 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043495 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046655 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047920 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | 1 | hsa-miR-16 | 19250063 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27077805 | In this study, curcumin promoted the expression of senescence marker Hmga1 in rat fibrotic liver |
| 25572145 | Another observation in the present study is the significant up-regulation of key senescence messaging factors regulated by NF-kappaB namely interleukin (IL)-6, IL-8, high-mobility group protein A (HMGA)1 and B (HMGB)1 in E2-transfected cells treated with TNF-alpha |
| 22932127 | RESULTS: We found that both deacetylation of H4-K16Ac and expression of HMGA1/2 can contribute to DNA compaction during senescence |
| 22932127 | CONCLUSIONS: Variable DNA compaction observed during senescence is explained in part by cell-type specific regulation of H4 deacetylation and HMGA1/2 expression |
| 19217096 | MAIN OUTCOME MEASURE(S): Senescence measured by percentage of SA-beta-Gal-positive cells; levels of let-7 microRNAs measured by RT-PCR and MISH; expression of p16(INK4a), Ki-67, HMGA1, and HMGA2 scaled by immunoreactivity |
| 18505920 | Although previous studies have established a prominent role for HMGA1 (formerly HMG-I/Y) in aggressive human cancers, the role of HMGA2 (formerly HMGI-C) in malignant transformation has not been clearly defined |
| 18505920 | The HMGA gene family includes HMGA1, which encodes the HMGA1a and HMGA1b protein isoforms, and HMGA2, which encodes HMGA2 |
| 18505920 | HMGA1 proteins also appear to participate in cell cycle regulation and malignant transformation, whereas HMGA2 has been implicated primarily in the pathogenesis of benign, mesenchymal tumors |
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