HCSGD entry for HMGCS2
1. General information
| Official gene symbol | HMGCS2 |
|---|---|
| Entrez ID | 3158 |
| Gene full name | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004421 | Hydroxymethylglutaryl-CoA synthase activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | IEA | biological_process |
| GO:0008299 | Isoprenoid biosynthetic process | IEA | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046950 | Cellular ketone body metabolic process | TAS | biological_process |
| GO:0046951 | Ketone body biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7337366323 | 0.8569840660 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0089203530 |
| GSE13712_SHEAR | Up | 0.1082274325 |
| GSE13712_STATIC | Down | -0.0753404729 |
| GSE19018 | Up | 0.1153742841 |
| GSE19899_A1 | Down | -0.0477463454 |
| GSE19899_A2 | Down | -0.0609968769 |
| PubMed_21979375_A1 | Up | 0.1783819735 |
| PubMed_21979375_A2 | Up | 0.0082044423 |
| GSE35957 | Up | 0.1064310635 |
| GSE36640 | Up | 0.1567626157 |
| GSE54402 | Down | -0.0992495261 |
| GSE9593 | Up | 0.0964881693 |
| GSE43922 | Down | -0.0073031954 |
| GSE24585 | Down | -0.0069145826 |
| GSE37065 | Up | 0.0477155768 |
| GSE28863_A1 | Down | -0.0160648766 |
| GSE28863_A2 | Up | 0.0520014677 |
| GSE28863_A3 | Up | 0.1683804278 |
| GSE28863_A4 | Up | 0.0932320386 |
| GSE48662 | Down | -0.0218270843 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
