HCSGD entry for HMGCR
1. General information
Official gene symbol | HMGCR |
---|---|
Entrez ID | 3156 |
Gene full name | 3-hydroxy-3-methylglutaryl-CoA reductase |
Other gene symbols | LDLCQ3 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0004420 | Hydroxymethylglutaryl-CoA reductase (NADPH) activity | IEA | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005778 | Peroxisomal membrane | IDA | cellular_component |
GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
GO:0006695 | Cholesterol biosynthetic process | IEA TAS | biological_process |
GO:0006743 | Ubiquinone metabolic process | IEA | biological_process |
GO:0007568 | Aging | IEA | biological_process |
GO:0007584 | Response to nutrient | IEA | biological_process |
GO:0008299 | Isoprenoid biosynthetic process | IEA | biological_process |
GO:0008542 | Visual learning | IEA | biological_process |
GO:0009790 | Embryo development | IEA | biological_process |
GO:0010664 | Negative regulation of striated muscle cell apoptotic process | IEA | biological_process |
GO:0010666 | Positive regulation of cardiac muscle cell apoptotic process | IEA | biological_process |
GO:0015936 | Coenzyme A metabolic process | IEA | biological_process |
GO:0016021 | Integral component of membrane | IEA | cellular_component |
GO:0032874 | Positive regulation of stress-activated MAPK cascade | IEA | biological_process |
GO:0042282 | Hydroxymethylglutaryl-CoA reductase activity | IDA IEA | molecular_function |
GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
GO:0043231 | Intracellular membrane-bounded organelle | IEA | cellular_component |
GO:0043407 | Negative regulation of MAP kinase activity | IEA | biological_process |
GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
GO:0044281 | Small molecule metabolic process | TAS | biological_process |
GO:0045445 | Myoblast differentiation | IEA | biological_process |
GO:0045471 | Response to ethanol | IEA | biological_process |
GO:0045908 | Negative regulation of vasodilation | IEA | biological_process |
GO:0048643 | Positive regulation of skeletal muscle tissue development | IEA | biological_process |
GO:0048661 | Positive regulation of smooth muscle cell proliferation | IEA | biological_process |
GO:0050662 | Coenzyme binding | IDA IEA | molecular_function |
GO:0051262 | Protein tetramerization | IDA | biological_process |
GO:0061045 | Negative regulation of wound healing | IEA | biological_process |
GO:0061179 | Negative regulation of insulin secretion involved in cellular response to glucose stimulus | IEA | biological_process |
GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | IEA | biological_process |
GO:0070402 | NADPH binding | IDA | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.0242339539 | 0.1324670339 | 0.3687063006 | 0.7011190026 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.8654098598 |
GSE13712_SHEAR | Down | -0.4022528217 |
GSE13712_STATIC | Down | -0.7168119405 |
GSE19018 | Down | -1.1121553136 |
GSE19899_A1 | Up | 1.1215387048 |
GSE19899_A2 | Up | 0.9410880328 |
PubMed_21979375_A1 | Up | 0.0564865352 |
PubMed_21979375_A2 | Up | 0.6286279895 |
GSE35957 | Up | 0.1238278878 |
GSE36640 | Up | 0.8814179665 |
GSE54402 | Up | 0.4631899662 |
GSE9593 | Up | 0.1014615885 |
GSE43922 | Up | 0.6457369233 |
GSE24585 | Down | -0.1240937242 |
GSE37065 | Up | 0.1831257112 |
GSE28863_A1 | Down | -0.3170399498 |
GSE28863_A2 | Up | 0.3315843510 |
GSE28863_A3 | Down | -0.8278087927 |
GSE28863_A4 | Down | -0.1783262485 |
GSE48662 | Down | -0.3830061379 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
Pravastatin | DB00175 | APRD00328 |
Cerivastatin | DB00439 | APRD00102 |
Atorvastatin | DB01076 | APRD00055 |
Fluvastatin | DB01095 | APRD00346 |
Rosuvastatin | DB01098 | APRD00546 |
Coenzyme A | DB01992 | EXPT00991 |
(S)-Hmg-Coa | DB03169 | EXPT01758 |
2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
3-Hydroxy-3-Methyl-Glutaric Acid | DB04377 | EXPT02109 |
1,4-Dithiothreitol | DB04447 | EXPT01291 |
TAK-475 | DB05317 | - |
SP-01A | DB05342 | - |
Mevastatin | DB06693 | - |
7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID | DB06846 | - |
Pitavastatin | DB08860 | DB06514 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-193b-3p | MIMAT0002819 | MIRT016598 | Microarray | Functional MTI (Weak) | 20304954 |
hsa-miR-335-5p | MIMAT0000765 | MIRT018888 | Microarray | Functional MTI (Weak) | 18185580 |
hsa-miR-29c-3p | MIMAT0000681 | MIRT020381 | Sequencing | Functional MTI (Weak) | 20371350 |
hsa-miR-32-5p | MIMAT0000090 | MIRT028289 | Sequencing | Functional MTI (Weak) | 20371350 |
hsa-miR-615-3p | MIMAT0003283 | MIRT040026 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-92a-3p | MIMAT0000092 | MIRT048980 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
23500545 | The mechanisms by which oxysterols may influence proliferation are manifold: they control the transcription and the turnover of the key enzyme in cholesterol synthesis, 3-hydroxy-3-methylglutaryl CoA reductase, by binding to Insig-1, Insig-2 and liver X receptors |
226108 | The activity of the enzyme hydroxymethylglutaryl-CoA reductase and its repression by LDL has also been investigated in these fibroblast strains and in senescent cells of the foetal lung cell strain MRC-5 |
Entries Per Page
Displaying Page of