HCSGD entry for HMGCR


1. General information

Official gene symbolHMGCR
Entrez ID3156
Gene full name3-hydroxy-3-methylglutaryl-CoA reductase
Other gene symbolsLDLCQ3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004420Hydroxymethylglutaryl-CoA reductase (NADPH) activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005778Peroxisomal membraneIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006695Cholesterol biosynthetic processIEA TASbiological_process
GO:0006743Ubiquinone metabolic processIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008299Isoprenoid biosynthetic processIEAbiological_process
GO:0008542Visual learningIEAbiological_process
GO:0009790Embryo developmentIEAbiological_process
GO:0010664Negative regulation of striated muscle cell apoptotic processIEAbiological_process
GO:0010666Positive regulation of cardiac muscle cell apoptotic processIEAbiological_process
GO:0015936Coenzyme A metabolic processIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0032874Positive regulation of stress-activated MAPK cascadeIEAbiological_process
GO:0042282Hydroxymethylglutaryl-CoA reductase activityIDA IEAmolecular_function
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043231Intracellular membrane-bounded organelleIEAcellular_component
GO:0043407Negative regulation of MAP kinase activityIEAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045445Myoblast differentiationIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045908Negative regulation of vasodilationIEAbiological_process
GO:0048643Positive regulation of skeletal muscle tissue developmentIEAbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0050662Coenzyme bindingIDA IEAmolecular_function
GO:0051262Protein tetramerizationIDAbiological_process
GO:0061045Negative regulation of wound healingIEAbiological_process
GO:0061179Negative regulation of insulin secretion involved in cellular response to glucose stimulusIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0070402NADPH bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02423395390.13246703390.36870630060.7011190026

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8654098598
GSE13712_SHEARDown-0.4022528217
GSE13712_STATICDown-0.7168119405
GSE19018Down-1.1121553136
GSE19899_A1Up1.1215387048
GSE19899_A2Up0.9410880328
PubMed_21979375_A1Up0.0564865352
PubMed_21979375_A2Up0.6286279895
GSE35957Up0.1238278878
GSE36640Up0.8814179665
GSE54402Up0.4631899662
GSE9593Up0.1014615885
GSE43922Up0.6457369233
GSE24585Down-0.1240937242
GSE37065Up0.1831257112
GSE28863_A1Down-0.3170399498
GSE28863_A2Up0.3315843510
GSE28863_A3Down-0.8278087927
GSE28863_A4Down-0.1783262485
GSE48662Down-0.3830061379

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
PravastatinDB00175 APRD00328
CerivastatinDB00439 APRD00102
AtorvastatinDB01076 APRD00055
FluvastatinDB01095 APRD00346
RosuvastatinDB01098 APRD00546
Coenzyme ADB01992 EXPT00991
(S)-Hmg-CoaDB03169 EXPT01758
2'-Monophosphoadenosine 5'-DiphosphoriboseDB03461 EXPT02293
3-Hydroxy-3-Methyl-Glutaric AcidDB04377 EXPT02109
1,4-DithiothreitolDB04447 EXPT01291
TAK-475DB05317 -
SP-01ADB05342 -
MevastatinDB06693 -
7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACIDDB06846 -
PitavastatinDB08860 DB06514

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016598MicroarrayFunctional MTI (Weak)20304954
hsa-miR-335-5pMIMAT0000765MIRT018888MicroarrayFunctional MTI (Weak)18185580
hsa-miR-29c-3pMIMAT0000681MIRT020381SequencingFunctional MTI (Weak)20371350
hsa-miR-32-5pMIMAT0000090MIRT028289SequencingFunctional MTI (Weak)20371350
hsa-miR-615-3pMIMAT0003283MIRT040026CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT048980CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23500545The mechanisms by which oxysterols may influence proliferation are manifold: they control the transcription and the turnover of the key enzyme in cholesterol synthesis, 3-hydroxy-3-methylglutaryl CoA reductase, by binding to Insig-1, Insig-2 and liver X receptors
226108The activity of the enzyme hydroxymethylglutaryl-CoA reductase and its repression by LDL has also been investigated in these fibroblast strains and in senescent cells of the foetal lung cell strain MRC-5
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