HCSGD entry for HLCS

1. General information

Official gene symbolHLCS
Entrez ID3141
Gene full nameholocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
Other gene symbolsHCS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000785ChromatinIDAcellular_component
GO:0004077Biotin-[acetyl-CoA-carboxylase] ligase activityIEAmolecular_function
GO:0004078Biotin-[methylcrotonoyl-CoA-carboxylase] ligase activityIEAmolecular_function
GO:0004079Biotin-[methylmalonyl-CoA-carboxytransferase] ligase activityIEAmolecular_function
GO:0004080Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005652Nuclear laminaIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0006768Biotin metabolic processTASbiological_process
GO:0008283Cell proliferationIMPbiological_process
GO:0009305Protein biotinylationIDAbiological_process
GO:0009374Biotin bindingIDAmolecular_function
GO:0016363Nuclear matrixIDAcellular_component
GO:0016570Histone modificationIDAbiological_process
GO:0018271Biotin-protein ligase activityIDA IMPmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0070781Response to biotinIDA IEAbiological_process
GO:0071110Histone biotinylationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.36126092470.71921012120.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0125271278
GSE13712_SHEARUp0.1588115602
GSE13712_STATICUp0.0117004119
GSE19018Down-0.1209299148
GSE19899_A1Down-0.1451044498
GSE19899_A2Up0.0468018057
PubMed_21979375_A1Down-0.2431111196
PubMed_21979375_A2Down-0.0646646394
GSE35957Up0.2602441037
GSE36640Up0.0697803305
GSE54402Down-0.0542304935
GSE9593Up0.3557476348
GSE43922Down-0.0674631176
GSE24585Up0.0613745328
GSE37065Down-0.2405519601
GSE28863_A1Up0.4787626653
GSE28863_A2Up0.4688575057
GSE28863_A3Down-0.0404829520
GSE28863_A4Up0.0120103152
GSE48662Up0.1594887621

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.