HCSGD entry for MR1
1. General information
| Official gene symbol | MR1 |
|---|---|
| Entrez ID | 3140 |
| Gene full name | major histocompatibility complex, class I-related |
| Other gene symbols | HLALS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001916 | Positive regulation of T cell mediated cytotoxicity | IEA | biological_process |
| GO:0002367 | Cytokine production involved in immune response | IEA | biological_process |
| GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | IEA | biological_process |
| GO:0003823 | Antigen binding | IBA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IBA | cellular_component |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019882 | Antigen processing and presentation | IBA | biological_process |
| GO:0032393 | MHC class I receptor activity | TAS | molecular_function |
| GO:0032611 | Interleukin-1 beta production | IEA | biological_process |
| GO:0032620 | Interleukin-17 production | IEA | biological_process |
| GO:0042605 | Peptide antigen binding | IEA | molecular_function |
| GO:0042612 | MHC class I protein complex | IEA | cellular_component |
| GO:0050829 | Defense response to Gram-negative bacterium | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2264938490 | 0.1030336765 | 0.9079416083 | 0.6149545125 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2851261684 |
| GSE13712_SHEAR | Down | -0.4243989611 |
| GSE13712_STATIC | Up | 0.1672274935 |
| GSE19018 | Down | -0.0078131597 |
| GSE19899_A1 | Down | -0.0323786736 |
| GSE19899_A2 | Down | -0.5757211045 |
| PubMed_21979375_A1 | Down | -0.5672431243 |
| PubMed_21979375_A2 | Down | -0.5417606679 |
| GSE35957 | Up | 0.3117680270 |
| GSE36640 | Up | 0.3166126523 |
| GSE54402 | Down | -0.8237476338 |
| GSE9593 | Up | 0.5036497695 |
| GSE43922 | Down | -0.6437543110 |
| GSE24585 | Up | 1.4946147456 |
| GSE37065 | Up | 0.2359477459 |
| GSE28863_A1 | Up | 0.0733027096 |
| GSE28863_A2 | Up | 0.1491803314 |
| GSE28863_A3 | Down | -0.7860518574 |
| GSE28863_A4 | Down | -0.0096336203 |
| GSE48662 | Up | 0.1683039125 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Anti-thymocyte Globulin (Rabbit) | DB00098 | BTD00040 | BIOD00040 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019837 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
