HCSGD entry for HLA-E
1. General information
| Official gene symbol | HLA-E |
|---|---|
| Entrez ID | 3133 |
| Gene full name | major histocompatibility complex, class I, E |
| Other gene symbols | EA1.2 EA2.1 HLA-6.2 MHC QA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0001916 | Positive regulation of T cell mediated cytotoxicity | IEA | biological_process |
| GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | IBA TAS | biological_process |
| GO:0002479 | Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | biological_process |
| GO:0002480 | Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent | TAS | biological_process |
| GO:0005102 | Receptor binding | IBA | molecular_function |
| GO:0005886 | Plasma membrane | IBA TAS | cellular_component |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0012507 | ER to Golgi transport vesicle membrane | TAS | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0030670 | Phagocytic vesicle membrane | TAS | cellular_component |
| GO:0031901 | Early endosome membrane | TAS | cellular_component |
| GO:0042590 | Antigen processing and presentation of exogenous peptide antigen via MHC class I | TAS | biological_process |
| GO:0042605 | Peptide antigen binding | IBA | molecular_function |
| GO:0042612 | MHC class I protein complex | IEA | cellular_component |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0050776 | Regulation of immune response | TAS | biological_process |
| GO:0060333 | Interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
| GO:0071556 | Integral component of lumenal side of endoplasmic reticulum membrane | TAS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0346408495 | 0.9625656890 | 0.4261199164 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2685084352 |
| GSE13712_SHEAR | Up | 0.0980672234 |
| GSE13712_STATIC | Up | 0.1730742893 |
| GSE19018 | Up | 0.6673441089 |
| GSE19899_A1 | Down | -0.1387310357 |
| GSE19899_A2 | Up | 0.4633520908 |
| PubMed_21979375_A1 | Up | 0.5792546325 |
| PubMed_21979375_A2 | Up | 0.2082781309 |
| GSE35957 | Up | 0.0305532689 |
| GSE36640 | Up | 1.7698123524 |
| GSE54402 | Down | -0.1620831894 |
| GSE9593 | Up | 0.5547174616 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.1204921953 |
| GSE28863_A2 | Up | 0.4107683267 |
| GSE28863_A3 | Down | -0.4386569898 |
| GSE28863_A4 | Down | -0.1923167789 |
| GSE48662 | Up | 0.1200596766 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-296-3p | MIMAT0004679 | MIRT038407 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049514 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26865365 | Extracellular HSP70s have a number of cytoprotective and immunomodulatory functions, the latter either in the context of facilitating the cross-presentation of immunogenic peptides via major histocompatibility complex (MHC) antigens or in the context of acting as "chaperokines" or stimulators of innate immune responses |
| 25787341 | Pro-inflammatory cytokines can attract and activate immune cells, the presentation of membrane bound immune ligands allows for specific recognition and promiscuous gene expression may function to generate an array of tissue restricted proteins that could subsequently be processed into peptides for presentation via MHC molecules |
| 24998350 | Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they contact |
| 24998350 | The interaction of maternal NK cell receptors belonging to the killer cell immunoglobulin-like receptor (KIR) family with trophoblast MHC class I molecules in pregnancy can regulate NK cell activation for secretion of pro-angiogenic factors that promote placental development |
| 22888763 | These peaks mapped to the Major Histocompatibility (MHC) locus on 6p21 and the INK4/ARF (CDKN2a/b) tumor suppressor locus on 9p21 |
| 19602548 | CD8(+) T-cell responses to MHC class I-restricted tumor epitopes, not just allogeneic antigens, may help mediate antileukemia effects after HSCT, but the specificity and function of such cells are not completely understood |
| 19602548 | Screening for antigen-specific T cells was accomplished with a peptide/MHC tetramer library |
| 19493573 | Trophoblast cells and many cancer cells that harbor foreign antigens may evade immunity by epigenetic silencing of key immune response genes, including MHC class I and II and CD40 |
| 19493573 | We show here that pre-treatment of trophoblast cells and certain cancer cells with agents that activate stress pathways (Ras oncogene, PMA or H2O2) and induce senescence can substantially enhance the induction of immune response genes (MHC class II, CD40, MICA, MICB) by HDACi and restore a vigorous IFN-gamma response in trophoblast cells and tumor cells |
| 18258400 | CD9 antigen, MHC class I chain-related sequence A (MICA) and cell division cycle 37 homolog (CDC37) were up-regulated, and bone morphogenetic protein 4 (BMP4), dickkopf-1 (DKK1), and transcription factor 7-like 1 (TCF7L1) were down-regulated in old cells |
| 16365422 | Of the mutant mice tested, old animals lacking MHC class I exhibited 7-fold fewer TCE than controls, with a 7-fold reduction in TCE |
| 16365422 | By contrast, animals lacking only one of the MHC class I molecules (Kb or Db), or IL-7R, or devoid of T cell renewal via adult thymectomy, all exhibited significant increases in TCE incidence |
| 11937715 | The expression levels of MyoD, myogenin, MHC and p21 were also reduced in these clones |
| 3183596 | The outcome of these transplantations (fusion or rejection) is controlled by genes of a highly polymorphic histocompatibility system that resembles in many respects the mammalian major histocompatibility complex (MHC) |
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