HCSGD entry for HLA-DRA

1. General information

Official gene symbolHLA-DRA
Entrez ID3122
Gene full namemajor histocompatibility complex, class II, DR alpha
Other gene symbolsHLA-DRA1 MLRW
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0002504Antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIIEAbiological_process
GO:0005764LysosomeIDAcellular_component
GO:0005765Lysosomal membraneIDA TAScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006955Immune responseIEA NASbiological_process
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019882Antigen processing and presentationIEAbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0030658Transport vesicle membraneTAScellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0030669Clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0031295T cell costimulationTASbiological_process
GO:0031902Late endosome membraneIDAcellular_component
GO:0032395MHC class II receptor activityNASmolecular_function
GO:0032588Trans-Golgi network membraneTAScellular_component
GO:0042613MHC class II protein complexIEAcellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79493931840.07679183160.99999024730.5238784197

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0495436566
GSE13712_SHEARUp0.0899904419
GSE13712_STATICUp0.0401543626
GSE19018Up0.2462526942
GSE19899_A1Up0.1066495854
GSE19899_A2Up0.1246883101
PubMed_21979375_A1Up0.1280506513
PubMed_21979375_A2Up0.0291301443
GSE35957Down-1.7288475654
GSE36640Up0.0932134113
GSE54402Down-0.0206871699
GSE9593Up0.0885445361
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.7882938202
GSE28863_A2Down-0.7635834827
GSE28863_A3Up0.0618195503
GSE28863_A4Down-0.0788728651
GSE48662Down-0.3200795009

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.