HCSGD entry for HLA-A

1. General information

Official gene symbolHLA-A
Entrez ID3105
Gene full namemajor histocompatibility complex, class I, A
Other gene symbolsHLAA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001916Positive regulation of T cell mediated cytotoxicityIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class IIBA IEA TASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0002480Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentTASbiological_process
GO:0005102Receptor bindingIBA IPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIBA TAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006955Immune responseIEA IMP NASbiological_process
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016032Viral processIEA TASbiological_process
GO:0016045Detection of bacteriumIMPbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0030670Phagocytic vesicle membraneTAScellular_component
GO:0031901Early endosome membraneTAScellular_component
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042605Peptide antigen bindingIBA IEAmolecular_function
GO:0042612MHC class I protein complexIEAcellular_component
GO:0050690Regulation of defense response to virus by virusTASbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31203201630.87299675540.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0515289182
GSE13712_SHEARUp0.1788453929
GSE13712_STATICUp0.1891008952
GSE19018Up0.7468707767
GSE19899_A1Down-0.1662752802
GSE19899_A2Up0.0328988234
PubMed_21979375_A1Down-0.1682471264
PubMed_21979375_A2Down-0.0447600815
GSE35957Down-0.1928251641
GSE36640Up0.3165336683
GSE54402Up0.0078612841
GSE9593Up0.0385968807
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.0560951345
GSE28863_A2Up0.1361569344
GSE28863_A3Down-0.0632944369
GSE28863_A4Up0.0391301638
GSE48662Up0.1029642665

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019424MicroarrayFunctional MTI (Weak)17612493
hsa-miR-9-5pMIMAT0000441MIRT021411MicroarrayFunctional MTI (Weak)17612493
hsa-miR-124-3pMIMAT0000422MIRT022132MicroarrayFunctional MTI (Weak)18668037
hsa-miR-183-5pMIMAT0000261MIRT025003SequencingFunctional MTI (Weak)20371350
hsa-miR-615-3pMIMAT0003283MIRT040433CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.