HCSGD entry for ACACA
1. General information
| Official gene symbol | ACACA |
|---|---|
| Entrez ID | 31 |
| Gene full name | acetyl-CoA carboxylase alpha |
| Other gene symbols | ACAC ACACAD ACC ACC1 ACCA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001894 | Tissue homeostasis | IEA | biological_process |
| GO:0003989 | Acetyl-CoA carboxylase activity | IEA ISS TAS | molecular_function |
| GO:0004075 | Biotin carboxylase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA ISS TAS | cellular_component |
| GO:0006084 | Acetyl-CoA metabolic process | IEA ISS | biological_process |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0006633 | Fatty acid biosynthetic process | IEA ISS | biological_process |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0006768 | Biotin metabolic process | TAS | biological_process |
| GO:0006853 | Carnitine shuttle | TAS | biological_process |
| GO:0016874 | Ligase activity | IEA | molecular_function |
| GO:0019432 | Triglyceride biosynthetic process | TAS | biological_process |
| GO:0031325 | Positive regulation of cellular metabolic process | TAS | biological_process |
| GO:0035338 | Long-chain fatty-acyl-CoA biosynthetic process | TAS | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044268 | Multicellular organismal protein metabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051289 | Protein homotetramerization | IEA ISS | biological_process |
| GO:0055088 | Lipid homeostasis | IEA | biological_process |
| GO:2001295 | Malonyl-CoA biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3040856882 | 0.1870758140 | 0.9999902473 | 0.8388137896 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0366587035 |
| GSE13712_SHEAR | Down | -0.0447851235 |
| GSE13712_STATIC | Down | -0.2642210127 |
| GSE19018 | Down | -0.3039112524 |
| GSE19899_A1 | Down | -0.2091657650 |
| GSE19899_A2 | Up | 0.3512243285 |
| PubMed_21979375_A1 | Down | -0.4581682512 |
| PubMed_21979375_A2 | Up | 0.0274395041 |
| GSE35957 | Down | -0.0440611878 |
| GSE36640 | Down | -0.3181343016 |
| GSE54402 | Up | 0.1546905915 |
| GSE9593 | Down | -0.3487987711 |
| GSE43922 | Down | -0.2801789721 |
| GSE24585 | Down | -0.1699129543 |
| GSE37065 | Down | -0.3386012638 |
| GSE28863_A1 | Up | 1.3355002997 |
| GSE28863_A2 | Up | 1.2055473660 |
| GSE28863_A3 | Down | -0.2072002551 |
| GSE28863_A4 | Up | 0.0009911020 |
| GSE48662 | Up | 0.2493568806 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017082 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030449 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032204 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032204 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041233 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042761 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042815 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046646 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049478 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
