HCSGD entry for HK2
1. General information
| Official gene symbol | HK2 |
|---|---|
| Entrez ID | 3099 |
| Gene full name | hexokinase 2 |
| Other gene symbols | HKII HXK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001678 | Cellular glucose homeostasis | IBA | biological_process |
| GO:0004340 | Glucokinase activity | IBA | molecular_function |
| GO:0004396 | Hexokinase activity | IEA TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005536 | Glucose binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006096 | Glycolysis | IBA IEA | biological_process |
| GO:0007595 | Lactation | IEA | biological_process |
| GO:0008637 | Apoptotic mitochondrial changes | IDA IEA | biological_process |
| GO:0008645 | Hexose transport | TAS | biological_process |
| GO:0008865 | Fructokinase activity | IBA | molecular_function |
| GO:0015758 | Glucose transport | TAS | biological_process |
| GO:0019158 | Mannokinase activity | IBA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046324 | Regulation of glucose import | IEA | biological_process |
| GO:0051156 | Glucose 6-phosphate metabolic process | IBA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0096983701 | 0.8219040044 | 0.2513551181 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1801980641 |
| GSE13712_SHEAR | Up | 0.4520551878 |
| GSE13712_STATIC | Up | 0.2672735394 |
| GSE19018 | Down | -0.3553979101 |
| GSE19899_A1 | Up | 0.6115117170 |
| GSE19899_A2 | Up | 0.9554059091 |
| PubMed_21979375_A1 | Up | 0.4837575438 |
| PubMed_21979375_A2 | Up | 0.7033188925 |
| GSE35957 | Down | -0.1762276442 |
| GSE36640 | Up | 0.5619323667 |
| GSE54402 | Up | 0.2494299596 |
| GSE9593 | Down | -0.0023679633 |
| GSE43922 | Up | 2.2004823467 |
| GSE24585 | Down | -0.8384864500 |
| GSE37065 | Up | 0.4140344016 |
| GSE28863_A1 | Up | 0.0359833908 |
| GSE28863_A2 | Up | 0.6657874915 |
| GSE28863_A3 | Down | -0.0693691168 |
| GSE28863_A4 | Down | -0.2075860782 |
| GSE48662 | Up | 0.1530829300 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-143-3p | MIMAT0000435 | MIRT006301 | Luciferase reporter assay | Functional MTI | 22354042 |
| hsa-miR-143-3p | MIMAT0000435 | MIRT006301 | Luciferase reporter assay | Functional MTI | 22593586 |
| hsa-miR-143-3p | MIMAT0000435 | MIRT006301 | Luciferase reporter assay | Functional MTI | 23376635 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT006944 | Luciferase reporter assay | Functional MTI | 22593586 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT006945 | Luciferase reporter assay//qRT-PCR | Functional MTI | 22593586 |
| hsa-miR-375 | MIMAT0000728 | MIRT019914 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020800 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027665 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-484 | MIMAT0002174 | MIRT041885 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23735887 | METHODS: Human kidney tubular epithelial cells (HK2) were treated with moderate hydrogen peroxide (H2O2) for oxidative stress, with or without cell cycle inhibition (apigenin, API) for cell senescence |
| 41984 | In the first period of the red cell life span the predominant form is similar to hexokinase II, while in the mature erythrocyte the predominant glucose phosphorylating activity resembles hexokinase I |
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