HCSGD entry for UBE2K
1. General information
| Official gene symbol | UBE2K |
|---|---|
| Entrez ID | 3093 |
| Gene full name | ubiquitin-conjugating enzyme E2K |
| Other gene symbols | E2-25K HIP2 HYPG LIG UBC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0016881 | Acid-amino acid ligase activity | IEA | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032434 | Regulation of proteasomal ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0034450 | Ubiquitin-ubiquitin ligase activity | IDA | molecular_function |
| GO:0070059 | Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | IEA | biological_process |
| GO:0070936 | Protein K48-linked ubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1764008358 | 0.9650048554 | 0.8244045455 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0597678186 |
| GSE13712_SHEAR | Up | 0.0648097913 |
| GSE13712_STATIC | Up | 0.0692060794 |
| GSE19018 | Down | -0.0788701965 |
| GSE19899_A1 | Up | 0.3120304389 |
| GSE19899_A2 | Up | 0.1471405786 |
| PubMed_21979375_A1 | Up | 0.1582311154 |
| PubMed_21979375_A2 | Up | 0.1662929845 |
| GSE35957 | Up | 0.0715843697 |
| GSE36640 | Down | -0.2300609390 |
| GSE54402 | Up | 0.2557300942 |
| GSE9593 | Down | -0.1396571502 |
| GSE43922 | Up | 0.2149746979 |
| GSE24585 | Up | 0.0429165862 |
| GSE37065 | Up | 0.1830374656 |
| GSE28863_A1 | Up | 0.1385866939 |
| GSE28863_A2 | Up | 0.2591878400 |
| GSE28863_A3 | Up | 0.1913972587 |
| GSE28863_A4 | Down | -0.1295507013 |
| GSE48662 | Up | 0.1774228812 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023304 | Proteomics | Functional MTI (Weak) | 21750653 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029298 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044916 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
