HCSGD entry for HIC1
1. General information
| Official gene symbol | HIC1 |
|---|---|
| Entrez ID | 3090 |
| Gene full name | hypermethylated in cancer 1 |
| Other gene symbols | ZBTB29 ZNF901 hic-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA IEA ISS | biological_process |
| GO:0000785 | Chromatin | ISS | cellular_component |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IDA IEA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030178 | Negative regulation of Wnt signaling pathway | IDA | biological_process |
| GO:0042826 | Histone deacetylase binding | IDA | molecular_function |
| GO:0043517 | Positive regulation of DNA damage response, signal transduction by p53 class mediator | ISS | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IDA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3989521295 | 0.1485625698 | 0.9999902473 | 0.7457263529 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7199950093 |
| GSE13712_SHEAR | Up | 0.7911181381 |
| GSE13712_STATIC | Up | 0.6886359067 |
| GSE19018 | Down | -0.2333078073 |
| GSE19899_A1 | Down | -0.2627589271 |
| GSE19899_A2 | Up | 0.3633333663 |
| PubMed_21979375_A1 | Down | -0.2451383748 |
| PubMed_21979375_A2 | Up | 0.0031373587 |
| GSE35957 | Down | -0.1707114846 |
| GSE36640 | Down | -0.3859237344 |
| GSE54402 | Down | -0.1637085170 |
| GSE9593 | Down | -0.1657673140 |
| GSE43922 | Up | 0.1010089538 |
| GSE24585 | Down | -0.1027317492 |
| GSE37065 | Down | -0.3065219373 |
| GSE28863_A1 | Up | 0.0725255474 |
| GSE28863_A2 | Down | -0.0057911999 |
| GSE28863_A3 | Up | 0.4031972441 |
| GSE28863_A4 | Up | 0.0640921352 |
| GSE48662 | Up | 0.1000573167 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017725 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22552606 | Hypermethylation of HIC1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer |
| 22552606 | Because chronic pancreatitis (CP) is a consistent risk factor for pancreatic cancer, the possible alteration and tumor contribute effects of hypermethylated in cancer-1 (HIC1) promoter methylation in CP was investigated |
| 22552606 | METHODS: Methylation of HIC1 promoter HIC1 and SIRT1 expression were detected in human normal pancreas (NP), CP and pancreatic adenocarcinoma tissues |
| 22552606 | Furthermore, HIC1/SIRT1 pathway was regulated by demethylating reagent and exogenous expression in PANC-1, BxPC-3 and AsPC-1 cell lines, cell biology behavior including proliferation, apoptosis, cell cycle and senescence were detected |
| 22552606 | RESULTS: The methylation of HIC1 promoter was demonstrated in 70 |
| 22552606 | Moreover, hypermethylation of HIC1 promoter and deregulation of HIC1 expression in pancreatic cancer were significantly related to high-stage tumor and older patient age |
| 22552606 | HIC1 promoter hypermethylation was also observed in pancreatic cancer cell lines including PANC-1, BxPC-3 and AsPC-1 |
| 22552606 | CONCLUSIONS: Our results indicate that hypermethylation of HIC1 promoter in CP may contribute to the aberrant expression of HIC1/SIRT1 pathway and then involve in the pancreatic carcinogenesis |
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