HCSGD entry for PIK3R4
1. General information
| Official gene symbol | PIK3R4 |
|---|---|
| Entrez ID | 30849 |
| Gene full name | phosphoinositide-3-kinase, regulatory subunit 4 |
| Other gene symbols | VPS15 p150 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0004672 | Protein kinase activity | NAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005770 | Late endosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005930 | Axoneme | ISS | cellular_component |
| GO:0006468 | Protein phosphorylation | NAS | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006661 | Phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1459994301 | 0.7128953877 | 0.7661474786 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0683026882 |
| GSE13712_SHEAR | Up | 0.0187683856 |
| GSE13712_STATIC | Up | 0.0088196034 |
| GSE19018 | Up | 0.0708632474 |
| GSE19899_A1 | Up | 0.0322292573 |
| GSE19899_A2 | Up | 0.0785920691 |
| PubMed_21979375_A1 | Up | 0.1307458716 |
| PubMed_21979375_A2 | Up | 0.2301484012 |
| GSE35957 | Down | -0.0337474211 |
| GSE36640 | Down | -0.2033271537 |
| GSE54402 | Down | -0.0588584719 |
| GSE9593 | Down | -0.0363683452 |
| GSE43922 | Up | 0.2393080977 |
| GSE24585 | Down | -0.0219287005 |
| GSE37065 | Up | 0.2870099150 |
| GSE28863_A1 | Up | 1.0144782867 |
| GSE28863_A2 | Up | 1.1936387791 |
| GSE28863_A3 | Down | -0.2177528839 |
| GSE28863_A4 | Down | -0.2779709390 |
| GSE48662 | Down | -0.5666790033 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004145 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036495 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-503-5p | MIMAT0002874 | MIRT041128 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-330-3p | MIMAT0000751 | MIRT043838 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
