HCSGD entry for NRG1

1. General information

Official gene symbolNRG1
Entrez ID3084
Gene full nameneuregulin 1
Other gene symbolsARIA GGF GGF2 HGL HRG HRG1 HRGA MST131 NDF SMDF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIEAbiological_process
GO:0000902Cell morphogenesisIEAbiological_process
GO:0003161Cardiac conduction system developmentIEAbiological_process
GO:0003222Ventricular trabecula myocardium morphogenesisIDAbiological_process
GO:0003712Transcription cofactor activityIDAmolecular_function
GO:0005102Receptor bindingIEA IPImolecular_function
GO:0005125Cytokine activityTASmolecular_function
GO:0005176ErbB-2 class receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0007154Cell communicationTASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIDAbiological_process
GO:0007171Activation of transmembrane receptor protein tyrosine kinase activityIDA NASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007416Synapse assemblyIEAbiological_process
GO:0007422Peripheral nervous system developmentIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0008083Growth factor activityIDA NASmolecular_function
GO:0008283Cell proliferationIDAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009790Embryo developmentIEAbiological_process
GO:0010469Regulation of receptor activityIC NASbiological_process
GO:0010667Negative regulation of cardiac muscle cell apoptotic processIDAbiological_process
GO:0014032Neural crest cell developmentTASbiological_process
GO:0016020MembraneNAScellular_component
GO:0016324Apical plasma membraneIDAcellular_component
GO:0016477Cell migrationIEAbiological_process
GO:0021781Glial cell fate commitmentIEAbiological_process
GO:0030296Protein tyrosine kinase activator activityIDAmolecular_function
GO:0030297Transmembrane receptor protein tyrosine kinase activator activityIC NASmolecular_function
GO:0030307Positive regulation of cell growthIDAbiological_process
GO:0030424AxonIEAcellular_component
GO:0030879Mammary gland developmentTASbiological_process
GO:0030971Receptor tyrosine kinase bindingNASmolecular_function
GO:0031594Neuromuscular junctionIEAcellular_component
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038127ERBB signaling pathwayIDAbiological_process
GO:0042060Wound healingIDA TASbiological_process
GO:0042177Negative regulation of protein catabolic processIEAbiological_process
GO:0042325Regulation of phosphorylationIDAbiological_process
GO:0042327Positive regulation of phosphorylationIDAbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043125ErbB-3 class receptor bindingIDA IPImolecular_function
GO:0043496Regulation of protein homodimerization activityTASbiological_process
GO:0043497Regulation of protein heterodimerization activityIDAbiological_process
GO:0043624Cellular protein complex disassemblyIGIbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045213Neurotransmitter receptor metabolic processIEAbiological_process
GO:0045785Positive regulation of cell adhesionIDAbiological_process
GO:0045859Regulation of protein kinase activityIDAbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0046579Positive regulation of Ras protein signal transductionIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048663Neuron fate commitmentIEAbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0051048Negative regulation of secretionIDAbiological_process
GO:0051155Positive regulation of striated muscle cell differentiationISSbiological_process
GO:0051897Positive regulation of protein kinase B signalingIEAbiological_process
GO:0055007Cardiac muscle cell differentiationISSbiological_process
GO:0055012Ventricular cardiac muscle cell differentiationIDAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIDAbiological_process
GO:0060379Cardiac muscle cell myoblast differentiationIDAbiological_process
GO:0060956Endocardial cell differentiationIDAbiological_process
GO:0061098Positive regulation of protein tyrosine kinase activityIC IDA NASbiological_process
GO:2000273Positive regulation of receptor activityIC NASbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00016518750.22501181570.03813947370.9122821935

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4926300191
GSE13712_SHEARUp0.8536120521
GSE13712_STATICUp0.9229310242
GSE19018Up0.0237157697
GSE19899_A1Up1.9595395752
GSE19899_A2Up4.3455024080
PubMed_21979375_A1Up4.0617431495
PubMed_21979375_A2Up3.7714246548
GSE35957Down-0.7664603734
GSE36640Up3.3339939112
GSE54402Up1.7350689946
GSE9593Down-0.1030768441
GSE43922Up2.1453697586
GSE24585Up0.0563047810
GSE37065Down-0.3186150639
GSE28863_A1Down-0.7983926643
GSE28863_A2Down-0.1018982695
GSE28863_A3Down-0.9438519765
GSE28863_A4Down-0.4271818692
GSE48662Up0.1544993522

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022506MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20668675Using the LT-expressing cells, we performed a genetic screen for anchorage-independent proliferation and identified Sensory and Motor Neuron Derived Factor (SMDF), a transmembrane class III isoform of Neuregulin 1
20668675In contrast to oncogenic Ras, SMDF induced enhanced proliferation in normal primary Schwann cells but did not trigger cellular senescence
20668675In cooperation with LT, SMDF drove anchorage-independent proliferation, loss of contact inhibition and tumourigenicity
18358537An OBGF400 neuronal phenotype was indicated by the recognition of a transfected neuronal progenitor-cell-specific tubulin-alpha1 gene promoter, intracellular presence of early neuronal markers (TuJ1, neuregulin-1, doublecortin and SOX2) and enhanced expression of neuronal- and progenitor lineage-active genes (MAP2, nestin, ENO and Syn1) compared to that of porcine epithelial cells
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