HCSGD entry for CXXC1
1. General information
| Official gene symbol | CXXC1 |
|---|---|
| Entrez ID | 30827 |
| Gene full name | CXXC finger protein 1 |
| Other gene symbols | 2410002I16Rik 5830420C16Rik CFP1 CGBP HsT2645 PCCX1 PHF18 SPP1 ZCGPC1 hCGBP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0016607 | Nuclear speck | IDA | cellular_component |
| GO:0018022 | Peptidyl-lysine methylation | IDA | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0035097 | Histone methyltransferase complex | IDA | cellular_component |
| GO:0042800 | Histone methyltransferase activity (H3-K4 specific) | IDA | molecular_function |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045322 | Unmethylated CpG binding | IDA | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0048188 | Set1C/COMPASS complex | IDA | cellular_component |
| GO:0051568 | Histone H3-K4 methylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6160856312 | 0.3633692869 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1951548819 |
| GSE13712_SHEAR | Down | -0.3311112423 |
| GSE13712_STATIC | Down | -0.1572400895 |
| GSE19018 | Down | -0.2816321029 |
| GSE19899_A1 | Down | -0.3349580361 |
| GSE19899_A2 | Down | -0.0782168116 |
| PubMed_21979375_A1 | Up | 0.5620750035 |
| PubMed_21979375_A2 | Up | 0.0866741455 |
| GSE35957 | Down | -0.5589350918 |
| GSE36640 | Down | -0.3237091550 |
| GSE54402 | Up | 0.3847975186 |
| GSE9593 | Down | -0.3483831620 |
| GSE43922 | Up | 0.0817696304 |
| GSE24585 | Down | -0.2708520703 |
| GSE37065 | Up | 0.0401359387 |
| GSE28863_A1 | Up | 0.1039289956 |
| GSE28863_A2 | Up | 0.0890891107 |
| GSE28863_A3 | Up | 0.2313583425 |
| GSE28863_A4 | Up | 0.1276750350 |
| GSE48662 | Up | 0.1498303543 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022879 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042903 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 10799292 | PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis |
| 10799292 | We identified a novel gene PCCX1 that encoded a nuclear protein carrying a PHD finger, a CXXC domain, and an acidic region |
| 10799292 | PCCX1 mRNA was expressed constitutively through stages of cellular aging and immortalization, but at the protein level, a shorter form lacking the C-terminal region appeared as the cells approached crisis |
| 10799292 | These results suggested that PCCX1 was activated by proteolytic cleavage, which removed the C-terminal inhibitory region |
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