HCSGD entry for ANXA5
1. General information
| Official gene symbol | ANXA5 |
|---|---|
| Entrez ID | 308 |
| Gene full name | annexin A5 |
| Other gene symbols | ANX5 ENX2 PP4 RPRGL3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004859 | Phospholipase inhibitor activity | TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005543 | Phospholipid binding | TAS | molecular_function |
| GO:0005544 | Calcium-dependent phospholipid binding | IDA IEA | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007596 | Blood coagulation | IEA | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0010033 | Response to organic substance | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0043086 | Negative regulation of catalytic activity | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
| GO:0050819 | Negative regulation of coagulation | IEA | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
| GO:0072563 | Endothelial microparticle | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8718919608 | 0.0501932449 | 0.9999902473 | 0.4198667302 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0436514123 |
| GSE13712_SHEAR | Up | 0.4564358213 |
| GSE13712_STATIC | Up | 0.0641174438 |
| GSE19018 | Up | 0.0758589172 |
| GSE19899_A1 | Down | -0.2106447208 |
| GSE19899_A2 | Down | -0.4997236519 |
| PubMed_21979375_A1 | Down | -0.9091564294 |
| PubMed_21979375_A2 | Down | -0.3522844011 |
| GSE35957 | Up | 0.2464828168 |
| GSE36640 | Up | 0.2114822578 |
| GSE54402 | Down | -0.3547230207 |
| GSE9593 | Up | 0.4274684327 |
| GSE43922 | Down | -0.3591483594 |
| GSE24585 | Up | 0.4072421796 |
| GSE37065 | Down | -0.0687731168 |
| GSE28863_A1 | Down | -0.3617894271 |
| GSE28863_A2 | Down | -0.2608782772 |
| GSE28863_A3 | Down | -0.1377734124 |
| GSE28863_A4 | Down | -0.4242475729 |
| GSE48662 | Down | -0.2554360890 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Alpha-Glycerophosphorylserine | DB02497 | EXPT01649 |
| L-thioproline | DB02846 | EXPT02664 |
| K201 | DB02929 | EXPT01958 |
| L-Alpha-Glycerophosphorylethanolamine | DB03484 | EXPT01637 |
| 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid | DB03935 | EXPT01845 |
| N,O6-Disulfo-Glucosamine | DB03959 | EXPT02898 |
| 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid | DB03981 | EXPT03166 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022801 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029721 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-330-5p | MIMAT0004693 | MIRT038248 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22728018 | Accumulation of annexin A5 at the nuclear envelope is a biomarker of cellular aging |
| 22728018 | Here we show that annexin A5 accumulates at the nuclear envelope during replicative and drug-induced cellular senescence in primary human fibroblasts |
| 22728018 | This new cellular aging phenotype that we have termed SA-ANX5 (senescence-associated accumulation at the nuclear envelope of annexin A5) is as efficient and quantitative as the well-established senescence-associated beta-galactosidase activity assay and p21 immunoreactivity |
| 22728018 | We also observed that depletion of annexin A5 by siRNA in human fibroblasts accelerates premature senescence through the p38MAP kinase pathway |
| 16887494 | Lactadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5 |
| 16887494 | The anionic phospholipid-binding protein, annexin A5, has been used to detect the presence of phosphatidylserine on the outer leaflet of the cell membrane |
| 16887494 | METHODS: The authors isolated and labeled lactadherin and annexin A5 with FITC and compared their ability to detect phosphatidylserine expression by flow cytometry |
| 16887494 | Also, in HL 60 cells undergoing apoptosis, lactadherin detected phosphatidylserine expression earlier than annexin A5 |
| 16887494 | CONCLUSIONS: The authors' studies show that FITC-lactadherin is a better probe than annexin A5 in detecting phosphatidylserine-expressing activated platelets, red cells, and apoptotic cells |
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