HCSGD entry for HFE

1. General information

Official gene symbolHFE
Entrez ID3077
Gene full namehemochromatosis
Other gene symbolsHFE1 HH HLA-H MVCD7 TFQTL2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001916Positive regulation of T cell mediated cytotoxicityIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class IIEAbiological_process
GO:0003823Antigen bindingIBAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005769Early endosomeIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006461Protein complex assemblyTASbiological_process
GO:0006879Cellular iron ion homeostasisTASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0010106Cellular response to iron ion starvationIEAbiological_process
GO:0019882Antigen processing and presentationIBAbiological_process
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0042446Hormone biosynthetic processIEAbiological_process
GO:0042605Peptide antigen bindingIEAmolecular_function
GO:0042612MHC class I protein complexIEAcellular_component
GO:0045177Apical part of cellIDAcellular_component
GO:0045178Basal part of cellIDAcellular_component
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0055037Recycling endosomeIDAcellular_component
GO:0060586Multicellular organismal iron ion homeostasisIEAbiological_process
GO:0097459Iron ion import into cellIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55660711980.09629006880.99999024730.5916085201

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1833149127
GSE13712_SHEARUp0.2544228849
GSE13712_STATICUp0.4957838370
GSE19018Up0.1441436298
GSE19899_A1Down-0.2596310320
GSE19899_A2Down-0.5003630954
PubMed_21979375_A1Down-0.4940904962
PubMed_21979375_A2Down-0.9130098584
GSE35957Up0.1137136557
GSE36640Up0.1750924586
GSE54402Down-0.5154762549
GSE9593Up0.5065405968
GSE43922Down-0.9174358419
GSE24585Up0.5330070327
GSE37065Up0.0534874907
GSE28863_A1Down-0.0749043184
GSE28863_A2Up0.1276866864
GSE28863_A3Down-0.3081820515
GSE28863_A4Down-0.0440916071
GSE48662Up0.0132466518

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23169885Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells
23169885PURPOSE: Hemochromatosis is a disorder of iron overload arising mostly from mutations in HFE
23169885HFE is expressed in retinal pigment epithelium (RPE), and Hfe(-/-) mice develop age-related iron accumulation and retinal degeneration associated with RPE hyperproliferation
23169885These features are seen in Hfe(-/-) RPE cells as well as in Hjv(-/-) RPE cells, providing a molecular basis for the hyperproliferative phenotype of Hfe(-/-) and Hjv(-/-) RPE cells
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