HCSGD entry for CFH
1. General information
| Official gene symbol | CFH |
|---|---|
| Entrez ID | 3075 |
| Gene full name | complement factor H |
| Other gene symbols | AHUS1 AMBP1 ARMD4 ARMS1 CFHL3 FH FHL1 HF HF1 HF2 HUS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0006956 | Complement activation | TAS | biological_process |
| GO:0006957 | Complement activation, alternative pathway | IEA | biological_process |
| GO:0008201 | Heparin binding | IDA | molecular_function |
| GO:0030449 | Regulation of complement activation | TAS | biological_process |
| GO:0043395 | Heparan sulfate proteoglycan binding | IDA | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1470550321 | 0.0100611641 | 0.7682881104 | 0.1989456864 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9665009105 |
| GSE13712_SHEAR | Down | -1.0989562076 |
| GSE13712_STATIC | Down | -0.5435001894 |
| GSE19018 | Down | -0.9676725231 |
| GSE19899_A1 | Down | -0.3112309159 |
| GSE19899_A2 | Down | -1.5514889081 |
| PubMed_21979375_A1 | Up | 1.1927726417 |
| PubMed_21979375_A2 | Down | -1.3850107263 |
| GSE35957 | Up | 0.8165456083 |
| GSE36640 | Up | 1.1094256775 |
| GSE54402 | Down | -1.3784781119 |
| GSE9593 | Up | 0.2406347621 |
| GSE43922 | Down | -0.5918384785 |
| GSE24585 | Down | -0.1061578423 |
| GSE37065 | Up | 0.2081367128 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.3926271341 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | MIRT000303 | Western blot | Functional MTI | 19540598 |
| hsa-miR-146a-5p | MIMAT0000449 | MIRT000303 | Western blot | Functional MTI | 18801740 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | NA | hsa-miR-146a | 19944095 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26654980 | Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration |
| 26654980 | Most important, we show for the first time that senescent ARPE-19 cells upregulated vascular endothelial growth factor (VEGF) and simultaneously downregulated complement factor H (CFH) expression |
| 23853351 | The increased frequencies of CRP ATG haplotypes and CFH 402 His allele indicate high mortality in the elderly |
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