HCSGD entry for HEXB

1. General information

Official gene symbolHEXB
Entrez ID3074
Gene full namehexosaminidase B (beta polypeptide)
Other gene symbolsENC-1AS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIEAbiological_process
GO:0001669Acrosomal vesicleIEAcellular_component
GO:0004553Hydrolase activity, hydrolyzing O-glycosyl compoundsIEAmolecular_function
GO:0004563Beta-N-acetylhexosaminidase activityIEAmolecular_function
GO:0005764LysosomeIEAcellular_component
GO:0005975Carbohydrate metabolic processIEA TASbiological_process
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006687Glycosphingolipid metabolic processTASbiological_process
GO:0006689Ganglioside catabolic processIEAbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0007040Lysosome organizationIEAbiological_process
GO:0007341Penetration of zona pellucidaIEAbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0008049Male courtship behaviorIEAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008360Regulation of cell shapeIEAbiological_process
GO:0008654Phospholipid biosynthetic processIEAbiological_process
GO:0009313Oligosaccharide catabolic processIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0019915Lipid storageIEAbiological_process
GO:0030203Glycosaminoglycan metabolic processIEA TASbiological_process
GO:0030204Chondroitin sulfate metabolic processTASbiological_process
GO:0030207Chondroitin sulfate catabolic processTASbiological_process
GO:0030212Hyaluronan metabolic processTASbiological_process
GO:0030214Hyaluronan catabolic processTASbiological_process
GO:0042339Keratan sulfate metabolic processTASbiological_process
GO:0042340Keratan sulfate catabolic processTASbiological_process
GO:0042552MyelinationIEAbiological_process
GO:0042803Protein homodimerization activityIDA IEAmolecular_function
GO:0043202Lysosomal lumenTAScellular_component
GO:0043615Astrocyte cell migrationIEAbiological_process
GO:0044267Cellular protein metabolic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0048477OogenesisIEAbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01300174010.95235777520.28418814261.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7785885132
GSE13712_SHEARUp0.1847301204
GSE13712_STATICUp0.2571450231
GSE19018Up1.1267975456
GSE19899_A1Up0.3199866833
GSE19899_A2Up0.2808809467
PubMed_21979375_A1Up0.1549752797
PubMed_21979375_A2Up0.4002999868
GSE35957Down-0.3272658627
GSE36640Up0.4624794896
GSE54402Up0.0034904911
GSE9593Up0.8432973310
GSE43922Up0.1244952501
GSE24585Up0.0018465738
GSE37065Up0.3795137321
GSE28863_A1Up0.1777449119
GSE28863_A2Up0.6118094986
GSE28863_A3Down-0.4035961297
GSE28863_A4Down-0.2928318079
GSE48662Down-0.3033934674

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-Acetamido-2-Deoxy-D-Glucono-1,5-LactoneDB02813 EXPT01570
3ar,5r,6s,7r,7ar-5-Hydroxymethyl-2-Methyl-5,6,7,7a-Tetrahydro-3ah-Pyrano[3,2-D]Thiazole-6,7-DiolDB03747 EXPT02338
(2r,3r,4s,5r)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-PiperidiniumDB03861 EXPT01846

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030011MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.