HCSGD entry for HEXA

1. General information

Official gene symbolHEXA
Entrez ID3073
Gene full namehexosaminidase A (alpha polypeptide)
Other gene symbolsTSD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIEAbiological_process
GO:0004553Hydrolase activity, hydrolyzing O-glycosyl compoundsIEAmolecular_function
GO:0004563Beta-N-acetylhexosaminidase activityIEAmolecular_function
GO:0005764LysosomeIEAcellular_component
GO:0005975Carbohydrate metabolic processIEA TASbiological_process
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006687Glycosphingolipid metabolic processTASbiological_process
GO:0006689Ganglioside catabolic processIEAbiological_process
GO:0007040Lysosome organizationIEAbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0019915Lipid storageIEAbiological_process
GO:0019953Sexual reproductionIEAbiological_process
GO:0030203Glycosaminoglycan metabolic processIEA TASbiological_process
GO:0030204Chondroitin sulfate metabolic processTASbiological_process
GO:0030207Chondroitin sulfate catabolic processTASbiological_process
GO:0030212Hyaluronan metabolic processTASbiological_process
GO:0030214Hyaluronan catabolic processTASbiological_process
GO:0042339Keratan sulfate metabolic processTASbiological_process
GO:0042340Keratan sulfate catabolic processTASbiological_process
GO:0042552MyelinationIEAbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0048667Cell morphogenesis involved in neuron differentiationIEAbiological_process
GO:0050884Neuromuscular process controlling postureIEAbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34544603170.76023396530.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1491522331
GSE13712_SHEARDown-0.0717693648
GSE13712_STATICUp0.0176092408
GSE19018Up0.2381258163
GSE19899_A1Down-0.1399110533
GSE19899_A2Down-0.1619918252
PubMed_21979375_A1Down-0.1514343839
PubMed_21979375_A2Up0.1507266779
GSE35957Up0.3158044874
GSE36640Up0.3348416506
GSE54402Down-0.1837654340
GSE9593Up0.2293353139
GSE43922Down-0.0620159084
GSE24585Up0.1734459266
GSE37065Up0.2625167010
GSE28863_A1Up0.0053341621
GSE28863_A2Down-0.0847651604
GSE28863_A3Down-0.0560183637
GSE28863_A4Down-0.0904167393
GSE48662Up0.6468105722

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028906MicroarrayFunctional MTI (Weak)19088304
hsa-miR-615-3pMIMAT0003283MIRT039954CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.